Evidence map›Paper›PMID 41600133›Full record

ReviewPlants (Basel, Switzerland)2026

A Comprehensive Review on Steviol Glycosides: Sources, Properties, Bioactivities, Sensory-Functional Enhancement and Bioproduction Strategies.

Liangzhen Jiang, Xun Zhao, Wei Li, Guiru Tang, Yiming Yuan, Jie Cheng, Jun Hua, Liang Zou

Abstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liangzhen JiangCollege of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Xun ZhaoCollege of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Wei LiSichuan Ingia Biosynthetic Co., Ltd., Chengdu 610200, China.
Guiru TangCollege of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Yiming YuanProvincial Key Laboratory of Biotechnology, Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, Xi'an 710069, China.
Jie ChengCollege of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.ORCID 0000-0002-0500-4233
Jun HuaSichuan Ingia Biosynthetic Co., Ltd., Chengdu 610200, China.
Liang ZouSichuan Engineering Technology Research Center of Coarse Cereal Industrialization, Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu 610106, China.

Funding

Chengdu Science and Technology Program 2024-YF08-00022-GXChengdu Science and Technology Program 2025-YF05-00585-SN
6 · The paper itself

Abstract

Steviol glycosides (SGs) are high-intensity, zero-calorie natural sweeteners with demonstrated safety and potential health benefits, positioning them as ideal sucrose substitutes for metabolic disorder management. However, their broad application is limited by inherent drawbacks such as bitterness, low solubility, and inefficient production systems. This review provides a comprehensive summary of recent advances in SG research, covering their sources, properties, and bioactivities. A particular focus is placed on innovative bioproduction strategies-including enzyme engineering, metabolic pathway optimization, and sustainable extraction techniques. Strategies to overcome these challenges through sensory-function enhancement-including formulation and structural modification-are discussed. Furthermore, it highlights emerging trends like microbial chassis-based production and next-generation sweetener design, providing actionable insights for overcoming industrial bottlenecks. By integrating multidisciplinary advances in bioengineering, sensory science, and sustainable processing, this review offers a forward-looking perspective on the development and application of SGs as functional sweeteners in the global food industry.

Indexed as

bioactivitybioproductionbiosynthesisengineeringglycosyltransferasesteviol glycoside

Identifiers

PMID41600133
PMCPMC12844822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.