Evidence map›Paper›PMID 41599923›Full record

ArticleNutrients2026

Integrated 16S rRNA Sequencing and Metabolomics Analysis Reveal the Protective Effects of (E)-Flavokawain A on AOM/DSS-Induced Colorectal Cancer in Mice.

Xin Zhang, Di Wang, Yang Wang, Meimei Wang, Juncheng Wang, Yue Sun, Siman Chen, Xinting Qu, Antong Xia, Hongxin Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xin ZhangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.ORCID 0009-0004-1541-7658
Di WangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Yang WangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Meimei WangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Juncheng WangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Yue SunSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Siman ChenSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Xinting QuSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Antong XiaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Hongxin LiuSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Jihui WangSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.
Meng LiuSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, China.ORCID 0000-0003-1784-3410

Funding

Guangdong Basic and Applied Basic Research Foundation 2023A1515110307Guangdong Basic and Applied Basic Research Foundation 2024A1515140046
6 · The paper itself

Abstract

(E)-Flavokawain A (FKA), the primary chalcone constituent of

Indexed as

ChalconesColorectal NeoplasmsMetabolomicsRNA, Ribosomal, 16SAnimalsAzoxymethaneDextran SulfateDisease Models, AnimalGastrointestinal MicrobiomeLipid MetabolismMaleMiceMice, Inbred C57BLAzoxymethaneChalconesDextran SulfateRNA, Ribosomal, 16Scolorectal cancer(E)-Flavokawain Agut microbiotametabolism

Identifiers

PMID41599923
PMCPMC12844620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.