Evidence map›Paper›PMID 41599836›Full record

Trial reportNutrients2026

Bioenhancer Assessment of Black Pepper with Turmeric on Self-Reported Pain Ratings in Adults: A Randomized, Cross-Over, Clinical Trial.

Leandra Durham, Robert A Oster, Matthew Ithurburn, Chelsi Reynolds, James O Hill, Daniel L Smith

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leandra DurhamDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
Robert A OsterDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0002-2247-8596
Matthew IthurburnAmerican Sports Medicine Institute, Birmingham, AL 35205, USA.ORCID 0000-0001-8533-3661
Chelsi ReynoldsDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.
James O HillDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.ORCID 0000-0003-4690-2264
Daniel L SmithDepartment of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35233, USA.

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
CTSA UM1 at the University of Alabama at BirminghamUM1TR004771 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PATRICE DELAFONTAINE, Orlando M Gutierrez · 2024 to 2026
$29.2M
UAB Pre-Doctoral Training Program in Obesity-Related ResearchT32HL105349 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2010 to 2026
$5.7M
McCormick Science Institute NANHLBI NIH HHS T32 HL105349NIDDK NIH HHS P30 DK056336NIH HHS P30DK056336 and P60DK079626NIH HHS UM1TR004771
6 · The paper itself

Abstract

backgroundChronic pain, which affects over 50 million adults in the United States, has stimulated growing interest in natural and nutrition-based remedies as adjuncts to pharmacologic therapies. Evidence suggests that turmeric and related extracts (i.e., curcuminoids) may provide pain relief, albeit often at levels above dietary ranges, while piperine from black pepper exhibits bioenhancer characteristics of relevance with dietary exposures.

objectiveTo test the effectiveness of dietarily relevant amounts of turmeric with and without black pepper on self-reported pain ratings among adults with chronic pain.

methodsA randomized, crossover clinical trial tested the effectiveness of turmeric only (one of three amounts within culinary ranges) or turmeric with black pepper to influence pain in adults ≥ 40 years of age. Participants (

resultsPain ratings from baseline to week 3 were reduced and statistically significant (

conclusionsConsuming dietarily relevant amounts of turmeric, either alone or with black pepper, appears to improve average pain ratings. This result suggests a feasible dietary option for further study of nutritional interventions for chronic pain management.

Indexed as

BioenhancersChronic PainCurcumaPiper nigrumPlant ExtractsAdultAgedAlkaloidsBenzodioxolesCross-Over StudiesFemaleHumansMaleMiddle AgedPain MeasurementPiperidinesAlkaloidsBenzodioxolesBioenhancersPiperidinespiperinePlant ExtractsPolyunsaturated Alkamidesturmeric extractchronic painculinary spicesecological momentary assessmentexperience sampling methodologynutrition interventionpainspices

Identifiers

PMID41599836
PMCPMC12844896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.