The Allosteric Regulation of the DNA-Binding Domain of p53 by the Intrinsically Disordered C-Terminal Domain.

Shangbo Ning, Chengwei Zeng, Huiwen Wang, Junfeng Zhang, Yun Xue, Yunjie Zhao

Abstract read

In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Computational Methods in Drug Development: From Molecular Modeling to Artificial Intelligence Technologies.Pharmaceuticals (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shangbo NingSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China.

Chengwei ZengInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.

Huiwen WangSchool of Physics and Engineering, Henan University of Science and Technology, Luoyang 471023, China.

Junfeng ZhangSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China.

Yun XueSchool of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China.

Yunjie ZhaoInstitute of Biophysics and Department of Physics, Central China Normal University, Wuhan 430079, China.ORCID 0000-0002-5256-9456

Funding

Huiwen Wang 12204154Junfeng Zhang 25A310006Shangbo Ning 26A180009

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

allosteric mechanismfree energy landscapesintrinsically disordered proteinsMM-PBSAmolecular dynamics

Identifiers

PMID41599722

DOI10.3390/ph19010124

PMCPMC12845269

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.