Evidence map›Paper›PMID 41599625›Full record

ArticlePharmaceuticals (Basel, Switzerland)2025

A Combined SIRT5 Activation and SIRT3 Inhibition Prevents Breast Cancer Spheroids Growth by Reducing HIF-1α and Mitophagy.

Federica Barreca, Michele Aventaggiato, Mario Cristina, Luigi Sansone, Manuel Belli, Maria Beatrice Lista, Gaia Francisci, Sergio Valente, Dante Rotili, Antonello Mai and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Federica BarrecaDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0009-0005-7552-0005
Michele AventaggiatoDepartment of Life Sciences, Health, and Health Professions, Link Campus University, 00165 Rome, Italy.ORCID 0000-0002-9466-0047
Mario CristinaLaboratory of Molecular, Cellular and Ultrastructural Pathology, IRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0001-7360-6650
Luigi SansoneLaboratory of Molecular, Cellular and Ultrastructural Pathology, IRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0003-3150-6461
Manuel BelliLaboratory of Molecular, Cellular and Ultrastructural Pathology, IRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0001-9183-6206
Maria Beatrice ListaDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Gaia FrancisciDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Sergio ValenteDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0002-2241-607X
Dante RotiliDepartment of Science, Roma Tre University, Viale Guglielmo Marconi, 446, 00146 Rome, Italy.ORCID 0000-0002-8428-8763
Antonello MaiDepartment of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.ORCID 0000-0001-9176-2382
Matteo Antonio RussoLaboratory of Molecular, Cellular and Ultrastructural Pathology, IRCCS San Raffaele Roma, 00166 Rome, Italy.ORCID 0000-0002-5847-6015
Marco TafaniDepartment of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.ORCID 0000-0001-7128-810X

Funding

Sapienza University of Rome Ateneo 2023
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

autophagyglutamine metabolismmitophagysirtuinstriple negative breast cancer

Identifiers

PMID41599625
PMCPMC12844701

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.