ReviewPharmaceuticals (Basel, Switzerland)2025
A Review of Traditional Chinese Medicine Formulations and Natural Active Ingredients with Therapeutic Potential for Male Infertility Targeting Oxidative Stress.
Review in Pharmaceuticals (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Bioactive Oil Blend Nanoemulsion Attenuates Depression-like Behavior Through Modulation of Neuroimmune-Related Inflammatory Pathways in Experimental Rheumatoid Arthritis.Life (Basel, Switzerland) · 2026Article
- A mechanistic study on the repair of cadmium-induced male infertility using Yishen Tongluo formula based on network toxicology and experimental validation.Frontiers in endocrinology · 2026Article
- Zebrafish as a translational platform for investigating multi-organ pharmacological interactions of traditional Chinese medicine.Frontiers in pharmacology · 2026Review
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Authors and funding
9 authors.
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Abstract
Male infertility has emerged as a significant global concern, with male factors accounting for approximately 30% to 50% of infertility cases. Oxidative stress is recognized as the primary pathological mechanism affecting sperm structure and function. The development and application of chemically synthesized drug therapies are limited by lengthy research and development processes and significant adverse effects. Conversely, Traditional Chinese Medicine (TCM) compounds offer promising clinical applications for enhancing male reproductive function, attributed to their distinctive advantages of multi-target coordination and holistic regulation. This paper systematically reviews classical TCM compounds, such as those that tonify the kidney and benefit essence, warm and invigorate kidney Yang, and replenish Qi and nourish blood. It also examines the molecular mechanisms of active natural ingredients, including flavonoids, polyphenols, terpenes, alkaloids, and polysaccharides. These compounds improve male fertility by modulating oxidative stress-related signaling pathways. Furthermore, this review anticipates future research trajectories and potential applications within this domain, with the objective of establishing a theoretical basis for the clinical treatment of idiopathic male infertility and the development of novel pharmacological interventions.
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