ArticlePolymers2026
pH-Responsive Polyethylene Oxide-Based Electrospun Nanofibers for Controlled Drug Release in Infected Wound Treatment.
Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Infected wounds form a complex microenvironment that creates difficulties for drug delivery. In this study, a composite fiber membrane based on polyethylene oxide (PEO) was prepared. The intention was to achieve on-demand drug release and integrate multiple functions by adjusting the material composition. The membrane uses PEO as the main framework and contains chitosan (CS) and ascorbic acid (Asc). CS leads to an increase in fiber diameter, while Asc makes the fibers thinner. The two components act together to influence the microstructure. In vitro drug release experiments showed that changing the CS content in the PEO matrix can affect the initial release rate and the duration of sustained release. The membrane also shows sensitivity to pH. Under slightly acidic conditions, drug release becomes faster, which is similar to the state of infected wounds. In addition, the membrane maintains antioxidant activity and can inhibit
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