Evidence map›Paper›PMID 41599312›Full record

ArticleMolecules (Basel, Switzerland)2026

Biodegradability and Ecotoxicity Profiles of Choline Acetate, Betaine, and L-Proline NADESs: A Hidden Threat for Eutrophication?

Nandish M Nagappa, Angelica Mero, Elena Husanu, Zeba Usmani, Matteo Oliva, Matilde Vieira Sanches, Giorgia Fumagalli, Andrea Mele, Andrea Mezzetta, Nicholas Gathergood and 3 more

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Nandish M NagappaDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 12618 Tallinn, Estonia.ORCID 0000-0002-0116-1661
Angelica MeroDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4198-8495
Elena HusanuCenter for Material Interfaces, Istituto Italiano di Tecnologia, 56025 Pontedera, Italy.ORCID 0000-0001-9436-7943
Zeba UsmaniDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 12618 Tallinn, Estonia.
Matteo OlivaInteruniversity Consortium of Marine Biology and Applied Ecology "G. Bacci", 47128 Livorno, Italy.ORCID 0000-0002-0008-0827
Matilde Vieira SanchesInteruniversity Consortium of Marine Biology and Applied Ecology "G. Bacci", 47128 Livorno, Italy.ORCID 0000-0002-9407-9594
Giorgia FumagalliInteruniversity Consortium of Marine Biology and Applied Ecology "G. Bacci", 47128 Livorno, Italy.
Andrea MeleDipartimento di Chimica, Materiali e Ingegneria Chimica "Giulio Natta", Politecnico di Milano, 20133 Milano, Italy.ORCID 0000-0002-0351-0538
Andrea MezzettaDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0002-4540-9948
Nicholas GathergoodSchool of Chemistry, College of Science, University of Lincoln, Lincoln LN6 7TS, UK.ORCID 0000-0002-9398-9799
Lorenzo GuazzelliDepartment of Pharmacy, University of Pisa, 56126 Pisa, Italy.ORCID 0000-0003-4655-2946
Carlo PrettiInteruniversity Consortium of Marine Biology and Applied Ecology "G. Bacci", 47128 Livorno, Italy.ORCID 0000-0003-4949-2088
Yevgen KarpichevDepartment of Chemistry and Biotechnology, Tallinn University of Technology (TalTech), 12618 Tallinn, Estonia.ORCID 0000-0003-2322-6750

Funding

ERA-NET 727473
6 · The paper itself

Abstract

Deep Eutectic Solvents (DESs), particularly Naturally Available Deep Eutectic Solvents (NADESs), are increasingly regarded as green solvents due to their low vapor pressure, non-flammability, thermal stability, strong solvent power, and low toxicity. In line with Green Chemistry principles, the use of renewable and biocompatible components such as amino acids, lipids, and naturally derived acids enables the development of more sustainable solvent systems. This study addresses the need for environmentally safer NADESs by evaluating their physico-chemical suitability and environmental impact. Fifteen NADESs were prepared using naturally derived components and assessed for environmental safety. Biodegradability was evaluated using the OECD 301D Closed Bottle Test (CBT), while toxicity toward

Indexed as

BetaineCholineDeep Eutectic SolventsEutrophicationProlineBiodegradation, EnvironmentalMicroalgaeBetaineCholineDeep Eutectic SolventsProlinebiodegradationclosed bottle testecotoxicityhydrogen bond acceptorhydrogen bond donornaturally available deep eutectic solventsRaphidocelis subcapitata

Identifiers

PMID41599312
PMCPMC12844321

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.