Evidence map›Paper›PMID 41599306›Full record

ArticleMolecules (Basel, Switzerland)2026

Sexual Hormones Determination in Biofluids by In-Vial Polycaprolactone Thin-Film Microextraction Coupled with HPLC-MS/MS.

Francesca Merlo, Silvia Anselmi, Andrea Speltini, Clàudia Fontàs, Enriqueta Anticó, Antonella Profumo

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Francesca MerloDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0003-1769-1760
Silvia AnselmiDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.
Andrea SpeltiniDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0002-6924-7170
Clàudia FontàsDepartment of Chemistry, University of Girona, C/Maria Aurèlia Capmany 69, 17003 Girona, Spain.ORCID 0000-0002-5947-4126
Enriqueta AnticóDepartment of Chemistry, University of Girona, C/Maria Aurèlia Capmany 69, 17003 Girona, Spain.ORCID 0000-0003-0053-0119
Antonella ProfumoDepartment of Chemistry, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy.ORCID 0000-0001-5697-9260

Funding

Ministerio de Ciencia, Innovación y Universidades PID2022-140312NB-C22/ MCIN/AEI/10.13039/501100011033/FEDERMinistero dell'università e della ricerca Dipartimenti di eccellenza 2023-2027
6 · The paper itself

Abstract

The in-vial microextraction technique is emerging as an alternative sample treatment, as it integrates sorbent preparation, adsorption, and desorption of analytes in a single device before instrumental analysis. In this work, the applicability of polycaprolactone polymeric film, recently used for the in-vial microextraction of sex hormones from environmental waters, is studied in a low-capacity format for unconjugated sex hormones determination in biological samples by HPLC-MS/MS. Its performance was evaluated in urine and serum, achieving extraction in a short time (10 and 30 min, in turn) and satisfactory elution with ethanol, with recovery in the range of 65-111% in urine, 55-122% in bovine serum albumin (BSA) solution, and 66-121% in fetal bovine serum (FBS). In the case of protein matrices, a dilution to 20 g L

Indexed as

Gonadal Steroid HormonesPolyestersTandem Mass SpectrometryAnimalsChromatography, High Pressure LiquidHumansLiquid Chromatography-Mass SpectrometryGonadal Steroid HormonespolycaprolactonePolyestersbioanalysisestrogensgreen sample preparationin-vial microextractionpolymeric filmprogestinsserumurine

Identifiers

PMID41599306
PMCPMC12843708

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.