ArticleMolecules (Basel, Switzerland)2026
Scaffold Simplification Yields Potent Antibacterial Agents That Target Bacterial Topoisomerases.
Lyubov Khudiakova, Kristina Komarova, Maxim Zhuravlev, Dmitry Deniskin, Alexey Golovanov, Artemiy Nichugovskiy, Kirill Babkin, Maria Zakharova, Mikhail Chudinov, Elizaveta Rogacheva and 8 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
18 authors.
Lyubov KhudiakovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0000-0001-5410-9333 Kristina KomarovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0000-0002-6827-4441 Maxim ZhuravlevLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0009-0004-1416-0336 Dmitry DeniskinLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Alexey GolovanovLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0000-0002-9198-2876 Artemiy NichugovskiyLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Kirill BabkinLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Maria ZakharovaLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.
Mikhail ChudinovLomonosov Institute of Fine Chemical Technologies, MIREA-Russian Technological University, Moscow 119454, Russia.ORCID 0000-0001-9735-9690 Elizaveta RogachevaPasteur Institute of Epidemiology and Microbiology, Saint Petersburg 197101, Russia.
Olga ShevtsovaDepartment of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskiye Gory, Moscow 119991, Russia.ORCID 0000-0002-0109-1210 Daria IpatovaDepartment of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskiye Gory, Moscow 119991, Russia.
Dmitry SkvortsovDepartment of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskiye Gory, Moscow 119991, Russia.ORCID 0000-0001-8336-8596 Dmitrii LukianovDepartment of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskiye Gory, Moscow 119991, Russia.ORCID 0000-0003-1413-9559 Maxim GureevLaboratory of Bio- and Cheminformatics, School of Computer Science, Physics and Technology, HSE University, Saint Petersburg 190121, Russia.ORCID 0000-0002-0385-922X Alexey LukinDepartment of Medical Chemistry, Institute of Chemistry, Saint Petersburg State University, Saint Petersburg 199034, Russia.ORCID 0000-0001-6162-4851 Funding
Ministry of Science and Higher Education of the Russian Federation FSFZ-2026-0007
6 · The paper itselfAbstract
This work describes the lead optimization of a promising class of antibacterial compounds, derived from a previously reported N-[4-(4-fluorophenoxy)phenyl]-6-(methylsulfonyl)-2,6-diazaspiro [3.4]octane-8-carboxamide (
Indexed as
Anti-Bacterial AgentsBacteriaDNA Topoisomerases, Type ITopoisomerase InhibitorsDNA GyraseHumansMicrobial Sensitivity TestsMolecular StructureStructure-Activity RelationshipAnti-Bacterial AgentsDNA GyraseDNA Topoisomerases, Type ITopoisomerase Inhibitorsamino biphenylsamino diphenyl ethersantibacterial agentsDNA gyraseDNA replication inhibitorsESKAPE pathogensscaffold simplificationtopoisomerase I
Identifiers
PMID41599289
PMCPMC12844012
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