Fatty Acid and Amino Acid Derivatives in Organocatalyzed Michael Additions.

Aljaž Flis, Helena Brodnik, Nejc Petek, Franc Požgan, Jurij Svete, Bogdan Štefane, Luka Ciber, Uroš Grošelj

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Aljaž FlisFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.

Helena BrodnikFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-0099-2236

Nejc PetekFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0003-3331-4885

Franc PožganFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0001-6040-294X

Jurij SveteFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0003-3339-3595

Bogdan ŠtefaneFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-8709-9853

Luka CiberFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-6631-1974

Uroš GrošeljFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-5186-9879

Funding

The Slovenian Research and Innovation Agency I0-0022The Slovenian Research and Innovation Agency P1-0179

6 · The paper itself

Abstract

Amino acid derivatives, such as β-keto esters and pyrrolones, were used as nucleophiles in organocatalyzed Michael additions to nitroalkene acceptors, while fatty acid derivatives acted as both nucleophiles (β-keto esters) and electrophiles (nitroalkene acceptors). Bifunctional noncovalent organocatalysts were employed as asymmetric organocatalysts. Twenty compounds-including fatty acid and amino acid derivatives, as well as fatty acid-amino acid conjugates-were prepared with enantioselectivities of up to 98%

Indexed as

Amino AcidsFatty AcidsCatalysisEstersMolecular StructureStereoisomerismAmino AcidsEstersFatty Acidsamino acidsasymmetric organocatalysisdiastereoselectivityenantioselectivityfatty acidsMichael additionnitroalkene acceptorspyrrolonestetronic acidβ-keto esters

Identifiers

PMID41599254

DOI10.3390/molecules31020204

PMCPMC12844414

What OpenQuestion holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.