Evidence map›Paper›PMID 41599199›Full record

ArticlePharmaceutics2026

Do Cenobamate Pharmacokinetics Change with Co-Administered Antiseizure Medications? An Exploratory Analysis of Responder Patients with Focal Drug-Resistant Epilepsy.

Bruno Charlier, Viviana Izzo, Giovanni Assenza, Anna Chiara Balsamo, Flavia Cirillo, Albino Coglianese, Carlo Di Bonaventura, Mariana Fernandes, Antonio Gambardella, Emanuele Cerulli Irelli and 5 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Bruno CharlierOperative Unit of Clinical Pharmacology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0000-0002-5076-3220
Viviana IzzoOperative Unit of Clinical Pharmacology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0000-0001-6066-7569
Giovanni AssenzaResearch Unit of Neurology, Department of Medicine and Surgery, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128 Roma, Italy.ORCID 0000-0003-3129-1982
Anna Chiara BalsamoOperative Unit of Clinical Pharmacology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.
Flavia CirilloDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Albino CoglianeseDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Salerno, Italy.ORCID 0000-0002-2724-8212
Carlo Di BonaventuraDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-1890-5409
Mariana FernandesDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Antonio GambardellaDepartment of Science of Health, School of Medicine, Magna Græcia University, 88100 Catanzaro, Italy.ORCID 0000-0001-7384-3074
Emanuele Cerulli IrelliDepartment of Human Neurosciences, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-3906-555X
Claudio LiguoriDepartment of Systems Medicine, University of Rome Tor Vergata, 00133 Rome, Italy.
Sandra RufoloOperative Unit of Clinical Pharmacology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0009-0009-7756-6241
Ilaria SammarraDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Græcia University, 88100 Catanzaro, Italy.ORCID 0000-0003-4136-9245
Amelia FilippelliOperative Unit of Clinical Pharmacology, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", 84131 Salerno, Italy.ORCID 0000-0002-8235-9118
Francesca Felicia OpertoNeurologic Clinic, Magna Græcia University, 88100 Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

antiseizure medicationcenobamatepharmacokineticstherapeutic drug monitoring

Identifiers

PMID41599199
PMCPMC12845072

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.