Evidence map›Paper›PMID 41599172›Full record

ArticlePharmaceutics2026

In Silico Studies and Biological Evaluation of Thiosemicarbazones as Cruzain-Targeting Trypanocidal Agents for Chagas Disease.

Lidiane Meier, Milena F C V de Melo, Heitor R Abreu, Isabella M E Oliveira, Larissa Sens, Thiago H Doring, Renata Krogh, Adilson Beatriz, Adriano D Andricopulo, Sumbal Saba and 2 more

Abstract read
In one paragraph

Article in Pharmaceutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lidiane MeierDepartment of Exact Sciences and Education, Blumenau Campus, Federal University of Santa Catarina, Blumenau 89065-100, SC, Brazil.
Milena F C V de MeloInstituto de Química, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.
Heitor R AbreuDepartment of Exact Sciences and Education, Blumenau Campus, Federal University of Santa Catarina, Blumenau 89065-100, SC, Brazil.
Isabella M E OliveiraLabSO, Instituto de Química, Universidade Federal de Goiás (UFG), Goiânia 74690-900, GO, Brazil.ORCID 0000-0003-3905-6880
Larissa SensInstituto Federal do Espírito Santo, Campus Itapina, Colatina 29717-000, ES, Brazil.
Thiago H DoringDepartment of Exact Sciences and Education, Blumenau Campus, Federal University of Santa Catarina, Blumenau 89065-100, SC, Brazil.ORCID 0000-0002-3611-9105
Renata KroghLaboratory of Medicinal and Computational Chemistry (LQMC), São Carlos Institute of Physics (IFSC), University of Sao Paulo (USP), São Carlos 13563-120, SP, Brazil.
Adilson BeatrizInstituto de Química, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.ORCID 0000-0001-6864-6092
Adriano D AndricopuloLaboratory of Medicinal and Computational Chemistry (LQMC), São Carlos Institute of Physics (IFSC), University of Sao Paulo (USP), São Carlos 13563-120, SP, Brazil.ORCID 0000-0002-0457-818X
Sumbal SabaLabSO, Instituto de Química, Universidade Federal de Goiás (UFG), Goiânia 74690-900, GO, Brazil.ORCID 0000-0002-6134-7249
Aldo S de OliveiraGulbenkian Institute for Molecular Medicine (GIMM), Faculty of Medicine, University of Lisbon, 1649-028 Lisbon, Portugal.
Jamal RafiqueInstituto de Química, Universidade Federal do Mato Grosso do Sul (UFMS), Campo Grande 79074-460, MS, Brazil.ORCID 0000-0002-2336-040X

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul Chamada Especial Fundect 16/2022 - Bioprospecção e Síntese de Produtos para a Saúde Humana e Animal - Nº do T.O.: 204/2022, Nº SIAFEM: 31818Fundação de Apoio a Pesquisa do Estado de Goiás Chamada Pública FAPEG Nº 05/2025 (PVE2025041000055)Fundação de Apoio a Pesquisa do Estado de Goiás Chamada Pública FAPEG/SES Nº 18/2025 (ARB2025191000003)National Council for Scientific and Technological Development 316687/2023-5, 309975/2022-0, 404172/2023-7, 405655/2023-1Universidade Federal de Mato Grosso do Sul 001
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADMETChagas diseasecruzain inhibitionmolecular dockingthiosemicarbazones

Identifiers

PMID41599172
PMCPMC12845094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.