Evidence map›Paper›PMID 41599101›Full record

ArticlePathogens (Basel, Switzerland)2026

Anthelmintic Activity of Protocatechuic Acid Against Ivermectin-Susceptible and Resistant

Jorge Alberto Cortes-Morales, Agustín Olmedo-Juárez, Manasés González-Cortazar, Alejandro Zamilpa, María Eugenia López-Arellano, Humberto Flores-Bustamante, Dante Avilés-Montes, Juan Manuel Rivas-González, César Sotelo-Leyva, David Osvaldo Salinas-Sánchez

Abstract read
In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jorge Alberto Cortes-MoralesLaboratorio de Fitoquímica y Productos Naturales del Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca C.P. 62209, Morelos, Mexico.ORCID 0000-0003-4083-3093
Agustín Olmedo-JuárezCentro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad (CENID-SAI, INIFAP), Carretera Federal Cuernavaca-Cuautla No. 8534, Col. Progreso, A.P. 206-CIVAC, Jiutepec C.P. 62574, Morelos, Mexico.ORCID 0000-0001-5499-7449
Manasés González-CortazarCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Xochitepec C.P. 62790, Morelos, Mexico.ORCID 0000-0002-3693-1670
Alejandro ZamilpaCentro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Argentina No. 1, Xochitepec C.P. 62790, Morelos, Mexico.ORCID 0000-0002-2233-5958
María Eugenia López-ArellanoCentro Nacional de Investigación Disciplinaria en Salud Animal e Inocuidad (CENID-SAI, INIFAP), Carretera Federal Cuernavaca-Cuautla No. 8534, Col. Progreso, A.P. 206-CIVAC, Jiutepec C.P. 62574, Morelos, Mexico.ORCID 0000-0002-8688-4411
Humberto Flores-BustamanteEscuela de Estudios Superiores del Jicarero, Universidad Autónoma del Estado de Morelos, Carretera Galeana-Tequesquitengo s/n, Colonia El Jicarero, Jojutla C.P. 62909, Morelos, Mexico.
Dante Avilés-MontesFacultad de Ciencias Biológicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca C.P. 62209, Morelos, Mexico.ORCID 0000-0002-0352-2395
Juan Manuel Rivas-GonzálezEscuela de Estudios Superiores del Jicarero, Universidad Autónoma del Estado de Morelos, Carretera Galeana-Tequesquitengo s/n, Colonia El Jicarero, Jojutla C.P. 62909, Morelos, Mexico.
César Sotelo-LeyvaFacultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas s/n, Ciudad Universitaria Sur, Chilpancingo C.P. 39000, Guerrero, Mexico.ORCID 0000-0002-4710-4590
David Osvaldo Salinas-SánchezLaboratorio de Fitoquímica y Productos Naturales del Centro de Investigación en Biodiversidad y Conservación, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa, Cuernavaca C.P. 62209, Morelos, Mexico.ORCID 0000-0003-0183-4560

Funding

INIFAP SIGI: 9254136498. "Anthelmintic effect of three phenolic acids in combination with ivermectin on an Haemonchus contortus isolate resistant to this drug"
6 · The paper itself

Abstract

The frequent and indiscriminate use of all classes of synthetic anthelmintics to deworm small ruminants has decreased their effectiveness in a worldwide problem of anthelmintic resistance. Using active plant metabolites with anthelmintic properties has become a suggested alternative to control parasitic helminths. The present study investigated the ovicidal and larvicidal activity of a fraction (CnF4) containing protocatechuic acid (3,4-dihydroxybenzoic acid) from

Indexed as

AnthelminticsDrug ResistanceHaemonchusHydroxybenzoatesIvermectinAnimalsLarvaPlant ExtractsAnthelminticsHydroxybenzoatesIvermectinPlant Extractsprotocatechuic acidanthelmintic resistanceegg hatch inhibitionlarval mortalityphenolic acidssmall ruminant

Identifiers

PMID41599101
PMCPMC12845097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.