Physalin F Promotes AFG3L2-Mediated Degradation of VISA/MAVS to Suppress Innate Immune Response to RNA Virus.

Abstract read

In one paragraph

Article in Pathogens (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiao-Nan GaoDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China.

Hong-Bing ShuDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0000-0001-9102-3272

Mi LiDepartment of Infectious Diseases, Medical Research Institute, Zhongnan Hospital of Wuhan University, Wuhan University, Frontier Science Center for Immunology and Metabolism, State Key Laboratory of Virology and Biosafety, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan 430071, China.ORCID 0000-0002-9767-8795

Funding

National Natural Science Foundation of China 32188101National Natural Science Foundation of China 32200713State Key R&D Program of China 2024YFA1306500

6 · The paper itself

Abstract

Upon RNA virus infection, viral RNA is sensed by the RIG-I-like receptors (RLRs), which signal through the adaptor protein VISA/MAVS to induce an innate antiviral response. How the VISA-mediated innate antiviral response is regulated and whether it can be targeted for drug development against diseases caused by RNA virus infection needs to be further investigated. Here we report that physalin F, a natural secosteroid isolated from

Indexed as

Adaptor Proteins, Signal TransducingImmunity, InnateRNA VirusesRNA Virus InfectionsSecosteroidsAnimalsAntiviral AgentsHumansMiceSignal TransductionAdaptor Proteins, Signal TransducingAntiviral AgentsMAVS protein, humanphysalin FSecosteroidsAFG3L2innate immunityphysalin FvirusVISA/MAVS

Identifiers

PMID41599057

DOI10.3390/pathogens15010074

PMCPMC12844614

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.