ArticlePathogens (Basel, Switzerland)2025
Evaluation of the Novel RITA MTBC Assay for Tuberculosis Detection: A Pilot Comparison with GeneXpert and BD MAX™.
Tomasz Bogiel, Małgorzata Zimna, Renata Żebracka, Katarzyna Dziwnik, Monika Montowska, Dorota Krawiecka, Dawid Nidzworski, Marta Skwarecka, Kasjan Szemiako, Sabina Nidzworska and 3 more
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In one paragraphArticle in Pathogens (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Tomasz BogielDepartment of Propaedeutics of Medicine and Infection Prevention Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, 9 Maria Skłodowska-Curie Street, 85-094 Bydgoszcz, Poland.ORCID 0000-0001-6787-1378 Małgorzata ZimnaDepartment of Microbiological Diagnostics, Kujawsko-Pomorskie Pulmonology Centre in Bydgoszcz, 85-326 Bydgoszcz, Poland.
Renata ŻebrackaDepartment of Microbiological Diagnostics, Kujawsko-Pomorskie Pulmonology Centre in Bydgoszcz, 85-326 Bydgoszcz, Poland.
Katarzyna DziwnikDepartment of Microbiological Diagnostics, Kujawsko-Pomorskie Pulmonology Centre in Bydgoszcz, 85-326 Bydgoszcz, Poland.
Monika MontowskaDepartment of Microbiological Diagnostics, Kujawsko-Pomorskie Pulmonology Centre in Bydgoszcz, 85-326 Bydgoszcz, Poland.
Dorota KrawieckaDepartment of Microbiological Diagnostics, Kujawsko-Pomorskie Pulmonology Centre in Bydgoszcz, 85-326 Bydgoszcz, Poland.
Dawid NidzworskiInstitute of Biotechnology and Molecular Medicine, 25 Kampinoska Street, 80-180 Gdansk, Poland.ORCID 0000-0003-0533-0837 Marta SkwareckaInstitute of Biotechnology and Molecular Medicine, 25 Kampinoska Street, 80-180 Gdansk, Poland.ORCID 0000-0002-6779-0962 Kasjan SzemiakoInstitute of Biotechnology and Molecular Medicine, 25 Kampinoska Street, 80-180 Gdansk, Poland.
Sabina NidzworskaInstitute of Biotechnology and Molecular Medicine, 25 Kampinoska Street, 80-180 Gdansk, Poland.ORCID 0000-0001-6218-8342 Marcin WoźniakDepartment of Forensic Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, 85-094 Bydgoszcz, Poland.ORCID 0000-0003-4491-3824 Kamil DrożdżDepartment of Molecular Medical Microbiology, Jagiellonian University Medical College in Cracow, 31-121 Krakow, Poland.
Agnieszka KrawczykDepartment of Molecular Medical Microbiology, Jagiellonian University Medical College in Cracow, 31-121 Krakow, Poland.ORCID 0000-0002-9719-9663 Funding
Nicolaus Copernicus University funds for the basic research activity of the Microbiology Department Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland PDB WF 839
6 · The paper itselfAbstract
Tuberculosis is still one of the leading infectious causes of morbidity and mortality worldwide. Rapid diagnosis is essential for effective treatment and control of tuberculosis transmission. In recent years, nucleic acid amplification tests (NAATs), such as GeneXpert MTB/RIF, BD MAX™, Xpert MTB/RIF-Ultra, have significantly improved tuberculosis diagnostics. However, they mainly require expensive and advanced equipment. The aim of our study was to assess the usefulness of the novel RITA MTBC assay in this diagnostic context. A total of 61 clinical specimens were tested using the RITA MTBC assay in comparison with established molecular diagnostic platforms (GeneXpert and BD MAX™), used as molecular reference assays. Culture and microscopy were performed as part of initial clinical assessment, but the comparative analysis focused on molecular assays to provide a relevant evaluation of diagnostic performance. Among 31 samples previously identified as positive for
Indexed as
Molecular Diagnostic TechniquesMycobacterium tuberculosisNucleic Acid Amplification TechniquesTuberculosisDNA, BacterialHumansPilot ProjectsRapid Diagnostic TestsSensitivity and SpecificityDNA, BacterialBD MAX™ MDR-TBGeneXpert MTB/RIFmolecular diagnosticsMycobacterium tuberculosisnucleic acid amplification testsrapid diagnosticstuberculosis
Identifiers
PMID41599005
PMCPMC12844691
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