Evidence map›Paper›PMID 41598188›Full record

ArticleLife (Basel, Switzerland)2025

Prevalence of PD-1 Inhibitor-Associated Peripheral Neuropathy: A Retrospective Cohort Study.

Suma Ganji-Angirekula, Nicole W Segada, Prit Hasan, Peter M Grace, Jian Wang, Xiaowen Sun, Saba Javed

Abstract read
In one paragraph

Article in Life (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Suma Ganji-AngirekulaDepartment of Emergency Medicine, UTHealth Houston McGovern Medical School, Houston, TX 77030, USA.
Nicole W SegadaDepartment of Anesthesiology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0009-0004-6249-3231
Prit HasanDepartment of Medicine, Sam Houston State University College of Osteopathic Medicine, Conroe, TX 77304, USA.ORCID 0009-0002-2659-0339
Peter M GraceLaboratories of Neuroimmunology, Department of Symptom Research, MD Anderson, Houston, TX 77030, USA.ORCID 0000-0002-8999-1220
Jian WangDepartment of Biostatistics, MD Anderson, Houston, TX 77006, USA.
Xiaowen SunDepartment of Biostatistics, MD Anderson, Houston, TX 77006, USA.
Saba JavedDepartment of Pain Medicine, Division of Anesthesiology, Critical Care Medicine, and Pain Medicine, MD Anderson, Houston, TX 77030, USA.ORCID 0000-0002-1028-8904

Funding

NIH HHS 1R01CA227064-22NIH HHS 1R01NS126252-22NIH HHS 1RF1NS113840-22
6 · The paper itself

Abstract

Immunotherapy is a promising treatment option for many cancers but is associated with the development of peripheral neuropathy in some patients. This retrospective cross-sectional EMR-based prevalence study was performed at MD Anderson Cancer Center with an aim to define the prevalence and epidemiology of Programmed Cell Death Protein 1 (PD-1) inhibitor-associated polyneuropathy. A total of 12,092 patients treated with a PD-1 inhibitor between 4 March 2016 and 18 June 2023 were identified and those on immunotherapy monotherapy were isolated. A total of 817 patients had documented neuropathy-associated with PD-1 inhibitor exposure, corresponding to a prevalence of 6.76% (6.76%, 95% CI 6.31-7.22). Data was stratified to assess for association between peripheral neuropathy and agent, sex, race, ethnicity, smoking and diabetes status. Patients identifying as "Other" race had higher prevalence of neuropathy compared to White or Caucasian patients (OR 1.514,

Indexed as

immunotherapyneuropathyPD-1 inhibitor

Identifiers

PMID41598188
PMCPMC12842998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.