Evidence map›Paper›PMID 41597726›Full record

ArticleMicroorganisms2026

Differences in the Biliary Microbiome Between Biliary Tract Cancer and Benign Biliary Disease.

Hye Ji Lee, Sung Hee Park, Sung Yong Han, Jong Hyun Lee, Dong Uk Kim, Hyung Il Seo

Abstract read
In one paragraph

Article in Microorganisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hye Ji LeeBiomedical Research Institute, Pusan National University Hospital, Pusan 49241, Republic of Korea.ORCID 0000-0002-2851-0390
Sung Hee ParkBiomedical Research Institute, Pusan National University Hospital, Pusan 49241, Republic of Korea.ORCID 0000-0001-5499-0773
Sung Yong HanBiomedical Research Institute, Pusan National University Hospital, Pusan 49241, Republic of Korea.
Jong Hyun LeeBiomedical Research Institute, Pusan National University Hospital, Pusan 49241, Republic of Korea.ORCID 0000-0002-9752-5860
Dong Uk KimDepartment of Internal Medicine, Gumi Medical Center, CHA University, Gumi 39233, Republic of Korea.ORCID 0000-0002-7208-7753
Hyung Il SeoBiomedical Research Institute, Pusan National University Hospital, Pusan 49241, Republic of Korea.ORCID 0000-0002-4132-7662

Funding

Biomedical Research Institute, Pusan National University Hospital 202100350001
6 · The paper itself

Abstract

Bile contains many bacteria that can contribute to various diseases. Therefore, identifying bile microbiome differences between benign and malignant conditions is essential. In this study, bile samples were collected aseptically from 141 patients with biliary tract cancer (BTC) or benign biliary diseases (BBDs) who underwent endoscopic retrograde cholangiopancreatography or biliary tract surgery. Quality control PCR was performed to amplify the V3-V4 region of the bacterial 16S rRNA gene. Metagenomic sequencing of bile was successfully performed in 35 of 56 samples collected from patients with BTC and 24 of 85 samples from patients with BBD. The mean alpha diversity values comprised 2.788 ± 2.833 and 2.319 ± 1.355 in the BBD and BTC groups, respectively (

Indexed as

bacteroidesbilebiliary benign diseasebiliary tract cancer

Identifiers

PMID41597726
PMCPMC12844354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.