Evidence map›Paper›PMID 41597581›Full record

ArticleMicroorganisms2025

Prebiotic Treatment During Pregnancy Prevents Social Deficits Associated with Autism Spectrum Disorder-like Behavior Induced by Maternal Immune Activation.

Frederico Rogério Ferreira, Guilherme Araujo Rouvier, Lucas Hassib, Raphael de Andrade Morraye, Yago Soares Pereira da Silva, Luís Fernando Saldanha da Gama, Iuri Souza Pereira, Angelica Oliveira Gomes, Maria Julia Granero Rosa, Ana Carolina de Morais-Scussel and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Frederico Rogério FerreiraOswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0001-5098-9775
Guilherme Araujo RouvierOswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.
Lucas HassibOswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.ORCID 0000-0001-8486-0216
Raphael de Andrade MorrayeLaboratory of Molecular Genetics and Omics, Genetics Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto 14049-900, SP, Brazil.
Yago Soares Pereira da SilvaOswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.
Luís Fernando Saldanha da GamaOswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.
Iuri Souza PereiraOswaldo Cruz Foundation, Oswaldo Cruz Institute, Rio de Janeiro 21040-360, RJ, Brazil.
Angelica Oliveira GomesLaboratory of Cell Interaction, Federal University of Triângulo Mineiro, Uberaba 38025-180, MG, Brazil.ORCID 0000-0001-8719-2794
Maria Julia Granero RosaLaboratory of Cell Interaction, Federal University of Triângulo Mineiro, Uberaba 38025-180, MG, Brazil.
Ana Carolina de Morais-ScusselLaboratory of Cell Interaction, Federal University of Triângulo Mineiro, Uberaba 38025-180, MG, Brazil.
Greice Andreotti de MolfettaLaboratory of Molecular Genetics and Omics, Genetics Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto 14049-900, SP, Brazil.ORCID 0000-0003-0946-5704
Wilson Araujo SilvaLaboratory of Molecular Genetics and Omics, Genetics Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto 14049-900, SP, Brazil.ORCID 0000-0001-9364-2886

Funding

CNPq 403318/2023-8Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.923410/2023-00Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/16731-6Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro E-26/SEI-260003/012160/2021
6 · The paper itself

Abstract

Maternal exposure to infectious agents has been associated with an increased risk of mental disorders in offspring, such as autism spectrum disorder. Evidence suggests that maternal immune responses during infection can significantly impact the neurodevelopment of the offspring, potentially affecting central nervous system functions in the future. Inulin is an indigestible soluble fiber that acts as a prebiotic. It promotes the production of short-chain fatty acids, such as butyrate, which can help inhibit the production of pro-inflammatory cytokines. Thus, this study aims to investigate whether inulin treatment during pregnancy can mitigate or reduce the impact of maternal immune activation (MIA) on the neurodevelopment of the offspring. Swiss mice were used in a dose-response study to evaluate the protective effects of inulin against maternal exposure to soluble

Indexed as

autism spectrum disordergut microbiomeinulinmaternal immune activationToxoplasma gondii

Identifiers

PMID41597581
PMCPMC12843959

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.