ArticleCells2026
Small Molecule Cocktail DLC79 Suppresses Gliomagenesis by Activating Ascl1 and Remodeling Transcriptome.
Chuxiao Mao, Zhancheng Deng, Zhuming Chen, Lirong Huang, Caiyun Wang, Gong Chen, Qingsong Wang
Abstract read
In one paragraphArticle in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
7 authors.
Chuxiao MaoKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Zhancheng DengKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Zhuming ChenKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Lirong HuangKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Caiyun WangKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.
Gong ChenKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.ORCID 0000-0002-1857-3670 Qingsong WangKey Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.ORCID 0000-0003-2622-171X Funding
the Guangdong Province Science and Technology Project of China 2018B030332001the Guangzhou Key Projects of Brain Science and Brain-Like Intelligence Technology 202206060002the National Natural Science Foundation of China 81472052the Natural Science Foundation of Guangdong Province of China 2020A1515010854the Program for Guangdong Introducing Innovative and Entrepreneurial Teams 2021ZT09Y552the Science and Technology Project in Guangzhou 202102070001
6 · The paper itselfAbstract
Glioblastoma (GBM) remains incurable due to its invasive growth and therapeutic resistance. While the neurogenic transcription factor-mediated reprogramming of glioma cells has been reported, pharmacological reprogramming offers a promising alternative due to its potential advantages for clinical translation. Using phenotype-driven screening, we identified a multi-target small-molecule cocktail DLC79 (DAPT, LDN193189, CHIR99021, I-BET762, and Isx9) that effectively reprograms human glioma cells into neuron-like cells by activating endogenous
Indexed as
Basic Helix-Loop-Helix ProteinsBrain NeoplasmsCarcinogenesisGliomaSmall Molecule LibrariesTranscriptomeAnimalsCell Line, TumorCell MovementCell ProliferationGene Expression Regulation, NeoplasticHumansMiceXenograft Model Antitumor AssaysASCL1 protein, humanBasic Helix-Loop-Helix ProteinsSmall Molecule LibrariesAscl1glioblastomapharmacological reprogrammingsmall moleculestumorigenicity suppression
Identifiers
PMID41597284
PMCPMC12839642
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