Integrative Epigenomic and Transcriptomic Profiling Define Malignancy- and Cluster-Specific Signatures in Pheochromocytomas and Paragangliomas.

Mouna Tabebi, Małgorzata Łysiak, Oliver Gimm, Peter Söderkvist

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mouna TabebiDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, 58183 Linköping, Sweden.ORCID 0000-0002-2873-161X

Małgorzata ŁysiakDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, 58183 Linköping, Sweden.ORCID 0000-0002-0244-759X

Oliver GimmDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, 58183 Linköping, Sweden.ORCID 0000-0002-0054-664X

Peter SöderkvistDepartment of Biomedical and Clinical Sciences (BKV), Linköping University, 58183 Linköping, Sweden.

Funding

Linköping University LiU Cancer，LiU-2022

6 · The paper itself

Abstract

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors primarily involving the adrenal medulla and its associated paraganglia, with heterogeneous clinical behavior and complex molecular drivers. This study aimed to characterize DNA methylation and gene expression patterns in PPGLs to understand the molecular differences between tumor subtypes and malignancy. We performed an integrative analysis of DNA methylation (Illumina EPIC 850K) and gene expression profiles (Affymetrix microarrays) in 24 PPGLs, comparing these with The Cancer Genome Atlas (TCGA) data, to delineate cluster- and malignancy-specific epigenetic patterns. Comparison between pseudohypoxic Cluster I and kinase-signaling Cluster II tumors revealed 13 differentially methylated CpG sites, with a specific CpG within

Indexed as

Adrenal Gland NeoplasmsEpigenomicsGene Expression ProfilingParagangliomaPheochromocytomaTranscriptomeCluster AnalysisCpG IslandsDNA MethylationEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansmethylationpheochromocytoma/paragangliomaTCGAtranscriptomic

Identifiers

PMID41597272

DOI10.3390/cells15020198

PMCPMC12839883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.