Evidence map›Paper›PMID 41597256›Full record

ArticleCells2026

Cerebellar Resistance to Amyloid Plaque Deposition and Elevated Microglial ECM Proteoglycan Uptake in 5xFAD Mice.

Carla Cangalaya, Henning Peter Düsedau, Ildiko Rita Dunay, Alexander Dityatev, Stoyan Stoyanov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Carla CangalayaMolecular Neuroplasticity Research Group, German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, Haus 64, D-39120 Magdeburg, Germany.ORCID 0000-0002-3525-8445
Henning Peter DüsedauInstitute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, D-39120 Magdeburg, Germany.
Ildiko Rita DunayInstitute of Inflammation and Neurodegeneration, Health Campus Immunology, Infectiology and Inflammation (GC-I3), Otto-von-Guericke-University, D-39120 Magdeburg, Germany.
Alexander DityatevMolecular Neuroplasticity Research Group, German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, Haus 64, D-39120 Magdeburg, Germany.ORCID 0000-0002-0472-0553
Stoyan StoyanovMolecular Neuroplasticity Research Group, German Center for Neurodegenerative Diseases (DZNE), Leipziger Str. 44, Haus 64, D-39120 Magdeburg, Germany.ORCID 0000-0002-2872-7709

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Project-ID 425899996DZNE Stiftung T0531/43703/2023/hhe
6 · The paper itself

Abstract

In both Alzheimer's disease (AD) patients and animal models, senile plaques are generally observed in the cerebral cortex rather than the cerebellum. The mechanisms underlying the regional resistance of the cerebellum to amyloid plaque deposition remain poorly understood. We investigated this cerebellar resistance using 5xFAD mice, an amyloidosis model with high expression of mutant human

Indexed as

CerebellumExtracellular MatrixMicrogliaPlaque, AmyloidProteoglycansAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsDisease Models, AnimalHumansMiceMice, TransgenicAmyloid beta-PeptidesAmyloid beta-Protein PrecursorProteoglycansAlzheimer’s diseasecerebellumcortexextracellular matrixmicrogliaperineuronal netsproteoglycanssynaptic pruning

Identifiers

PMID41597256
PMCPMC12839178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.