Evidence map›Paper›PMID 41597246›Full record

ArticleCells2026

Preserved Function of Endothelial Colony-Forming Cells in Female Rats with Intrauterine Growth Restriction: Protection Against Arterial Hypertension and Arterial Stiffness?

Thea Chevalley, Floriane Bertholet, Marion Dübi, Maria Serena Merli, Mélanie Charmoy, Sybil Bron, Manon Allouche, Alexandre Sarre, Nicole Sekarski, Stéphanie Simoncini and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Thea ChevalleyDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0009-0002-7050-264X
Floriane BertholetDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
Marion DübiDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0001-9236-2583
Maria Serena MerliDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0009-0009-8779-6120
Mélanie CharmoyDepartment of Oncology UNIL CHUV, University of Lausanne, 1011 Lausanne, Switzerland.
Sybil BronDepartment of Oncology UNIL CHUV, University of Lausanne, 1011 Lausanne, Switzerland.
Manon AlloucheDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
Alexandre SarreDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0009-0008-7374-8278
Nicole SekarskiDepartment of Paediatric Cardiology, Lausanne University Hospital, University of Lausanne, 1011 Lausanne, Switzerland.
Stéphanie SimonciniUFR de Pharmacie, Campus Santé, Centre de Recherche en Cardiovasculaire et Nutrition, Institut National de la Santé et de la Recherche Médicale, Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement, Aix Marseille University, 13385 Marseille, France.ORCID 0000-0002-8062-5005
Patrick TafféCenter for Primary Care and Public Health (Unisanté), University of Lausanne, 1011 Lausanne, Switzerland.
Umberto SimeoniDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
Catherine YzydorczykDOHaD Laboratory, Department Woman-Mother-Child, Division of Pediatrics, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.ORCID 0000-0002-0617-7558

Funding

Association pour l'Information et la Recherche sur les maladies rénales Génétiques no number
6 · The paper itself

Abstract

Individuals born after intrauterine growth restriction (IUGR) are at increased risk of long-term cardiovascular complications, including elevated blood pressure, endothelial dysfunction, and arterial stiffness. Endothelial progenitor cells (EPCs), particularly endothelial colony-forming cells (ECFCs), play a critical role in maintaining vascular homeostasis. Previously, Simoncini et al. observed that in a rat model of IUGR, six-month-old males exhibited elevated systolic blood pressure (SBP) and microvascular rarefaction compared with control (CTRL) rats. These vascular alterations were accompanied by reduced numbers and impaired function of bone marrow-derived ECFCs, which were associated with oxidative stress and stress-induced premature senescence (SIPS). In contrast, IUGR females of the same age and from the same litter did not exhibit higher SBP or microvascular rarefaction, raising the question of whether ECFC dysfunction in IUGR female rats can be present without vascular alterations. So, we investigated ECFCs isolated from six-month-old female IUGR offspring (maternal 9% casein diet) and CTRL females (23% casein diet). To complete the vascular assessment, we performed in vivo and in vitro investigations. No alteration in pulse wave velocity (measured by echo-Doppler) was observed; however, IUGR females showed decreased aortic collagen and increased elastin content compared with CTRL. Regarding ECFCs, those from IUGR females maintained their endothelial identity (CD31

Indexed as

Endothelial Progenitor CellsFetal Growth RetardationHypertensionVascular StiffnessAnimalsBlood PressureDevelopmental Origins of Health and DiseaseFemaleMaleNitric Oxide Synthase Type IIIOxidative StressRatsNitric Oxide Synthase Type IIIarterial hypertensionarterial stiffnessendothelial colony-forming cellsintrauterine growth restrictionoxidative stressstress-induced premature senescence

Identifiers

PMID41597246
PMCPMC12839992

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.