Evidence map›Paper›PMID 41597229›Full record

ArticleCells2026

Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension.

Viranuj Sueblinvong, Sarah S Chang, Jing Ma, David R Archer, Solomon Ofori-Acquah, Roy L Sutliff, Changwon Park, C Michael Hart, Benjamin T Kopp, Bum-Yong Kang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Viranuj SueblinvongDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.ORCID 0000-0002-4770-5900
Sarah S ChangDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Jing MaDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
David R ArcherDepartment of Pediatrics, Division of Hematology, Oncology, and BMT, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA.ORCID 0000-0002-9185-0865
Solomon Ofori-AcquahDepartment of Pediatrics, Division of Hematology, Oncology, and BMT, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Roy L SutliffNational Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0001-8628-6975
Changwon ParkDepartment of Molecular and Cellular Physiology, Louisiana State University Health Science Center, Shreveport, LA 71103, USA.
C Michael HartDepartment of Medicine, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Benjamin T KoppDepartment of Pediatrics, Division of Pulmonology, Asthma, Cystic Fibrosis, and Sleep Medicine, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Bum-Yong KangAtlanta Veterans Affairs Healthcare System, Decatur, GA 30033, USA.ORCID 0000-0001-8251-1637

Funding

NIH HHS 5R01AA029690-01A1NIH HHS 5R01HL102167-08NIH HHS 5R01HL119291-06A1NIH HHS 5R01HL133053-04NIH HHS 5R03AA027662-02NIH HHS 5UL1TR002378-04United States Department of Veterans Affairs I01BX004263
6 · The paper itself

Abstract

Pulmonary hypertension (PH) causes morbidity and mortality in sickle cell disease (SCD). The release of heme during hemolysis triggers endothelial dysfunction and contributes to PH. Long non-coding RNAs (lncRNAs) may play a pivotal role in endothelial dysfunction and PH pathogenesis. This study assessed the regulatory role of the lncRNA-heme oxygenase-1 (HMOX1) axis in SCD-associated PH pathogenesis. Total RNAs were isolated from the lungs of 15-17-week-old sickle cell (

Indexed as

Anemia, Sickle CellHeme Oxygenase-1Hypertension, PulmonaryMembrane ProteinsRNA, Long NoncodingAnimalsEndothelial CellsEndothelin-1Gene Expression RegulationHeminHumansLungMaleMiceUp-RegulationEndothelin-1Heme Oxygenase-1HeminHmox1 protein, mouseMalat1 long non-coding RNA, mouseMembrane ProteinsRNA, Long Noncodingendothelial dysfunctionlncRNAMALAT1pulmonary hypertensionsickle cell disease

Identifiers

PMID41597229
PMCPMC12839230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.