Candidate Interaction Partners of Calpain-5 Suggest Clues to Its Involvement in Neovascular Inflammatory Vitreoretinopathy.

Jozsef Gal, Vimala Bondada, Rachel Crasta, Dorothy E Croall, Calvin P Vary, James W Geddes

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jozsef GalSpinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, KY 40536, USA.ORCID 0000-0002-5865-6534

Vimala BondadaSpinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, KY 40536, USA.

Rachel CrastaSpinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, KY 40536, USA.

Dorothy E CroallDepartment of Molecular and Biomedical Sciences, University of Maine, Orono, ME 04469, USA.ORCID 0000-0001-8214-8911

Calvin P VaryGraduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME 04469, USA.

James W GeddesSpinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, KY 40536, USA.

Funding

Kentucky Spinal Cord and Head Injury Research Trust N/ANIH HHS 5R01NS095229-05

6 · The paper itself

Abstract

Although calpain-5/CAPN5 is widely expressed in mammals, little is known regarding its functions. Pathogenic mutations of CAPN5 are causal for a devastating autoimmune eye disease, neovascular inflammatory vitreoretinopathy (NIV). To provide insight into both the physiological and pathological roles of CAPN5, it is essential to identify candidate interaction partners and possible substrates. Human SH-SY5Y neuroblastoma cells, transfected with full-length catalytically dead (Cys81Ala) CAPN5-3×FLAG, were used for anti-FLAG co-immunoprecipitation (co-IP) and quantitative proteomics using Sequential Window Acquisition of all THeoretical mass spectra (SWATH-MS). Fifty-one proteins were enriched at least four-fold,

Indexed as

CalpainVitreoretinopathy, ProliferativeCell Line, TumorHumansImmunoprecipitationProtein BindingProteolysisProteomicsCalpainCapn5 protein, humanCAPN5diseaseinteractionmembraneneurodegenerationNIVproteomicssubstratevitreoretinopathy

Identifiers

PMID41597217

DOI10.3390/cells15020142

PMCPMC12839053

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.