Evidence map›Paper›PMID 41597212›Full record

ArticleCells2026

BAP31 Modulates Mitochondrial Homeostasis Through PINK1/Parkin Pathway in MPTP Parkinsonism Mouse Models.

Wanting Zhang, Shihao Meng, Zhenzhen Hao, Xiaoshuang Zhu, Lingwei Cao, Qing Yuan, Bing Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wanting ZhangCollege of Life Science and Health, Northeastern University, Shenyang 110169, China.
Shihao MengCollege of Life Science and Health, Northeastern University, Shenyang 110169, China.
Zhenzhen HaoCollege of Life Science and Health, Northeastern University, Shenyang 110169, China.
Xiaoshuang ZhuCollege of Life Science and Health, Northeastern University, Shenyang 110169, China.
Lingwei CaoJiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
Qing YuanJiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China.
Bing WangCollege of Life Science and Health, Northeastern University, Shenyang 110169, China.ORCID 0000-0002-6549-8837

Funding

the National Natural Science Foundation of China 31972898
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder characterized by age-dependent degeneration of dopaminergic neurons in the substantia nigra, a process mediated by α-synuclein aggregation, mitochondrial dysfunction, and impaired proteostasis. While BAP31-an endoplasmic reticulum protein critical for protein trafficking and degradation-has been implicated in neuronal processes, its role in PD pathogenesis remains poorly understood. To investigate the impact of BAP31 deficiency on PD progression, we generated dopamine neuron-specific BAP31 conditional knockout with DAT-Cre (cKO) mice (Slc6a3cre-BAP31

Indexed as

HomeostasisMembrane ProteinsMitochondriaParkinsonian DisordersProtein KinasesUbiquitin-Protein LigasesAnimalsDisease Models, AnimalDopaminergic NeuronsMaleMiceMice, Inbred C57BLMice, KnockoutPTEN-Induced Putative KinaseSignal TransductionMembrane Proteinsparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesBAP31EN1mitochondrial homeostasisParkinson’s diseasePINK1–Parkin pathway

Identifiers

PMID41597212
PMCPMC12839962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.