Evidence map›Paper›PMID 41597207›Full record

ArticleCells2026

Aberrant Cell Cycle Gene Expression in a Transgenic Mouse Model of Alzheimer's Disease.

Marika Lanza, Michele Scuruchi, Alessandra Saitta, Rossella Basilotta, Federica Aliquò, Giovanna Casili, Emanuela Esposito, Agata Copani, Salvatore Oddo, Antonella Caccamo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marika LanzaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Michele ScuruchiDepartment of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria n.1, 98125 Messina, Italy.ORCID 0000-0002-5282-1690
Alessandra SaittaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Rossella BasilottaDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Federica AliquòDepartment of Biomedical Sciences, Dental Sciences, and Morpho-Functional Imaging, University of Messina, Via Consolare Valeria n.1, 98125 Messina, Italy.
Giovanna CasiliDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Emanuela EspositoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0002-2663-6387
Agata CopaniDepartment of Drug and Health Sciences, University of Catania, 95125 Catania, Italy.ORCID 0000-0003-3730-2590
Salvatore OddoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.ORCID 0000-0001-7304-7430
Antonella CaccamoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.

Funding

Italian Ministry of University and Research PRIN_2022PNRR_P202278YHJ_002.
6 · The paper itself

Abstract

Alzheimer's disease (AD) is increasingly recognized as a disorder that extends beyond amyloid-β (Aβ) and tau pathology. To this end, growing evidence suggests that aberrant neuronal cell cycle re-entry (CCR) may contribute to neurodegeneration. To investigate this mechanism, we profiled the expression of 84 cell cycle-related genes in the brains of aged APP/PS1 mice, a widely used transgenic model of AD, and compared them with age-matched non-transgenic littermates. Our analysis revealed 32 differentially expressed genes (DEGs), 8 of which exhibited significant changes (fold change > 2,

Indexed as

Alzheimer DiseaseCell CycleGene Expression RegulationAmyloid beta-Protein PrecursorAnimalsBrainDisease Models, AnimalGene Expression ProfilingHumansMiceMice, TransgenicMicroRNAsNeuronsAmyloid beta-Protein PrecursorMicroRNAsAlzheimer’s diseasecell cycle re-entrydifferentially expressed genes

Identifiers

PMID41597207
PMCPMC12839143

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.