Evidence map›Paper›PMID 41597183›Full record

ArticleCells2026

Targeting Lung Cancer Cell Motility Using Microbeam Radiation Therapy.

Ömer Dağkazanlı, Aleksandra Čolić, Rainer Lindner, Stefan Bartzsch, Stephanie E Combs, Thomas E Schmid, Marina Santiago Franco

Abstract read
In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ömer DağkazanlıDepartment of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.ORCID 0009-0006-8890-9260
Aleksandra ČolićDepartment of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.
Rainer LindnerInstitute of Radiation Medicine (IRM), Helmholtz Zentrum München GmbH, German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Stefan BartzschDepartment of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.ORCID 0000-0001-9550-9122
Stephanie E CombsDepartment of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.
Thomas E SchmidDepartment of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.
Marina Santiago FrancoDepartment of Radiation Oncology, TUM School of Medicine and Health and Klinikum Rechts der Isar, University Hospital of the Technical University of Munich, Ismaninger Straße 22, 81675 Munich, Germany.ORCID 0000-0003-4610-1328

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) Projektnummer (492331627)
6 · The paper itself

Abstract

Radiotherapy (RT) is currently among the standard treatments for lung cancer. However, in vitro studies have revealed that irradiation can increase lung cancer cell motility. This way, RT could potentially enhance the malignancy of solid tumors post-treatment, promoting metastasis. Therefore, there is a continued need to continue evolving RT modalities into safer and more effective treatments. The present study compares the impact of the broad beam (BB) and the spatially fractionated modality of microbeam radiation therapy (MRT) on the motility of A549 lung cancer cells. Our data corroborates previous findings that showed BB irradiation is a promoter of cell motility. For MRT, however, we observed a prevention of cellular migration. A significant reduction in

Indexed as

Cell MovementLung NeoplasmsA549 CellsCell Line, TumorFibroblastsHumansNeoplasm InvasivenessNF-kappa BTumor MicroenvironmentNF-kappa BCD44invasionirradiationmetastasismigrationNF-κBspatial fractionation

Identifiers

PMID41597183
PMCPMC12839417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.