Response of Oral and Skin Keratinocytes to Oxidative Stress.

Yixuan Zhang, Chen Han, Heidi Yuan, Luisa A DiPietro, Lin Chen

Abstract read

In one paragraph

Article in Cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

TLR4-paxillin-Rac1 signaling mediates LPS-induced dysregulation of keratinocyte function.iScience · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yixuan ZhangDepartment of Dermatology, The Fourth Affiliated Hospital of Soochow University (Medical Center of Soochow University), Suzhou 215000, China.ORCID 0009-0009-5450-9471

Chen HanCenter for Wound Healing and Tissue Regeneration, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0003-1662-6561

Heidi YuanCenter for Wound Healing and Tissue Regeneration, University of Illinois Chicago, Chicago, IL 60612, USA.

Luisa A DiPietroCenter for Wound Healing and Tissue Regeneration, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0002-4842-1547

Lin ChenCenter for Wound Healing and Tissue Regeneration, University of Illinois Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8530-2363

Funding

China Gusu Talent Program GSWS2023118Jiangsu Province "Double Innovation Doctor" Program JSSCBS20230518NIH HHS 1F31AR082287-03NIH HHS 1F31AR083830-03NIH HHS 1R35GM139603-04

6 · The paper itself

Abstract

Oxidative stress caused by excessive reactive oxygen species (ROS) disrupts skin and oral epithelial homeostasis and contributes to skin aging, inflammation, periodontitis, and mucosal injury. As the principal defenders in both skin and oral mucosal tissues, keratinocytes are important responders to oxidative stress. However, most existing studies have examined skin or oral keratinocytes in isolation, with few comparative investigations of their tolerance, repair capacity, and antioxidant mechanisms under oxidative stress. In this study, we systematically compared immortalized oral keratinocytes (TIGK) and skin keratinocytes (HaCaT) under hydrogen peroxide (H

Indexed as

KeratinocytesMouthOxidative StressSkinAntioxidantsCell LineCell MovementCell ProliferationCell SurvivalHaCaT CellsHumansHydrogen PeroxideReactive Oxygen SpeciesWound HealingAntioxidantsHydrogen PeroxideReactive Oxygen Speciesantioxidant defensekeratinocytesoraloxidative stressreactive oxygen speciesskin

Identifiers

PMID41597175

DOI10.3390/cells15020097

PMCPMC12839278

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.