Evidence map›Paper›PMID 41596770›Full record

ArticleInternational journal of molecular sciences2026

Microenvironment Modulates Tumorigenicity of Breast Cancer Cells Depending on Hormone Receptor Status.

Priscila Pagnotta, Tomás González-Garello, María Luján Crosbie, Natalia Santiso, Anabela Ursino, Celeste Frascarolli, Alicia Amato, Rubén Dreszman, Juan Carlos Calvo, Judith Toneatto

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Priscila PagnottaInstituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, Argentina.ORCID 0000-0003-4918-9740
Tomás González-GarelloInstituto de Cálculo (IC), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Av. Int. Cantilo, Buenos Aires 1428, Argentina.ORCID 0000-0002-7736-5994
María Luján CrosbieComplejo Médico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina.ORCID 0009-0003-7444-2979
Natalia SantisoComplejo Médico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina.
Anabela UrsinoComplejo Médico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina.
Celeste FrascarolliComplejo Médico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina.
Alicia AmatoComplejo Médico Policial Churruca-Visca, Uspallata 3400, Buenos Aires 1437, Argentina.
Rubén DreszmanClínica de Microcirugía, Bulnes 1813, Buenos Aires 1425, Argentina.
Juan Carlos CalvoInstituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, Argentina.ORCID 0000-0001-7632-611X
Judith ToneattoInstituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Vuelta de Obligado 2490, Buenos Aires 1428, Argentina.ORCID 0000-0003-4764-4199

Funding

Honorio Bigand Foundation, the Williams Foundation and the René Barón Foundation N/CNational Scientific and Technical Research Council of Argentina #2414
6 · The paper itself

Abstract

Adipose tissue plays a crucial role in breast cancer (BC) progression by actively modulating the tumor microenvironment. We investigated how tumor proximity modifies adipose tissue by analyzing selected adipose-related and prognosis-associated markers in explants from BC patients and healthy donors. Explants were categorized by proximity to the tumor as

Indexed as

Breast NeoplasmsCarcinogenesisReceptors, EstrogenReceptors, ProgesteroneTumor MicroenvironmentAdipose TissueBiomarkers, TumorCaveolin 1Cell Line, TumorCell MovementCulture Media, ConditionedFemaleGene Expression Regulation, NeoplasticHumansHyaluronan ReceptorsKruppel-Like Factor 4Biomarkers, TumorCaveolin 1Culture Media, ConditionedHyaluronan ReceptorsKLF4 protein, humanKruppel-Like Factor 4Matrix Metalloproteinase 9Receptors, EstrogenReceptors, ProgesteroneVimentinhormone receptorshuman breast adipose tissuetumorigenesistumor microenvironment

Identifiers

PMID41596770
PMCPMC12842586

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.