Evidence map›Paper›PMID 41596761›Full record

ReviewInternational journal of molecular sciences2026

Molecular Genetics of β-Cell Compensation in Gestational Diabetes Mellitus: Insights from CDKAL1, SLC30A8 and HHEX.

Justyna Hryniewicka, Angelika Buczyńska-Backiel, Monika Zbucka-Krętowska, Adam Jacek Krętowski, Małgorzata Szelachowska

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Associations ofBiomolecules · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Justyna HryniewickaDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.ORCID 0000-0003-3894-3218
Angelika Buczyńska-BackielClinical Research Centre, Medical University of Bialystok, ul. M. Skłodowskiej-Curie 24a, 15-276 Bialystok, Poland.ORCID 0000-0001-7403-6928
Monika Zbucka-KrętowskaDepartment of Gynecological Endocrinology and Adolescent Gynecology, Medical University of Bialystok, ul. M. Skłodowskiej-Curie 24a, 15-276 Bialystok, Poland.
Adam Jacek KrętowskiDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.ORCID 0000-0002-4522-4978
Małgorzata SzelachowskaDepartment of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, ul. M. Sklodowskiej-Curie 24a, 15-276 Bialystok, Poland.

Funding

Medical University of Białystok B.SUB.23.502
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy associated with significant short- and long-term risks for both mother and offspring. Increasing evidence indicates that genetic susceptibility plays a central role in GDM pathogenesis, particularly through variants affecting insulin secretion and pancreatic β-cell function. This narrative review integrates molecular, clinical, and epidemiological perspectives, highlighting population-specific effects and gene-environment interactions. Improved understanding of the genetic risk architecture may support earlier risk stratification and enable the future development of personalized strategies for GDM prevention and management, with particular emphasis on genetic polymorphisms in

Indexed as

Diabetes, GestationalHomeodomain ProteinsInsulin-Secreting CellsTranscription FactorstRNA MethyltransferasesZinc Transporter 8AnimalsFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansInsulinPregnancyCDKAL1 protein, humanHHEX protein, humanHomeodomain ProteinsInsulinSLC30A8 protein, humanTranscription FactorstRNA MethyltransferasesZinc Transporter 8genetic determinantsgenetic patternsgestational diabetes mellitusmaternal-fetal imbalancesmolecular mechanisms

Identifiers

PMID41596761
PMCPMC12842414

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.