Evidence map›Paper›PMID 41596760›Full record

ReviewInternational journal of molecular sciences2026

A Decade-Old Atlas of TMEM (Transmembrane) Protein Family in Lung Cancer: Lessons Learnt and Future Directions.

Siwei Zhang, Guojie Cao, Xuelin Hu, Chen Chen, Peng Chen

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siwei ZhangExperimental Center of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.ORCID 0000-0002-1035-1088
Guojie CaoExperimental Center of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.
Xuelin HuExperimental Center of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.
Chen ChenExperimental Center of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.
Peng ChenExperimental Center of Biochemistry and Molecular Biology, Faculty of Basic Medical Science, Xi'an Medical University, Xi'an 710021, China.

Funding

Xi'an Medical University 2023BS32
6 · The paper itself

Abstract

A growing body of work has linked the dysregulation of transmembrane (TMEM) proteins to the proliferation, metastasis, drug resistance, and tumor microenvironment remodeling of lung cancer, the leading global cause of cancer mortality. Renamed members such as STING1 (stimulator of interferon response cGAMP interactor 1, TMEM173), ANO1 (anoctamin-1, TMEM16A), ORAI1 (ORAI calcium release-activated calcium modulator 1, TMEM142A), ORAI3 (TMEM142C), and NDC1 (NDC1 transmembrane nucleoporin, TMEM48) are among the most extensively studied ones. Mechanisms of TMEM dysregulation in lung cancer span the modulation of Ca

Indexed as

Lung NeoplasmsMembrane ProteinsAnimalsGene Expression Regulation, NeoplasticHumansTumor MicroenvironmentMembrane ProteinsGene Expression Profiling Interactive Analysis 2 (GEPIA2)lung cancersignaling pathwaystransmembrane (TMEM) protein

Identifiers

PMID41596760
PMCPMC12841848

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.