Evidence map›Paper›PMID 41596707›Full record

ArticleInternational journal of molecular sciences2026

SIAH2-WNK1 Signaling Drives Glycolytic Metabolism and Therapeutic Resistance in Colorectal Cancer.

Kee-Thai Kiu, Cheng-Ying Chu, Yi-Chiao Cheng, Min-Hsuan Yen, Ying-Wei Chen, Narpati Wesa Pikatan, Vijesh Kumar Yadav, Tung-Cheng Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kee-Thai KiuDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, New Taipei City 235, Taiwan.ORCID 0000-0001-9703-7480
Cheng-Ying ChuCRISPR Gene Targeting Core, Taipei Medical University, Taipei 110, Taiwan.ORCID 0000-0003-1002-8640
Yi-Chiao ChengDivision of Colon and Rectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei 114, Taiwan.ORCID 0000-0001-8317-1339
Min-Hsuan YenDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, New Taipei City 235, Taiwan.
Ying-Wei ChenDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, New Taipei City 235, Taiwan.
Narpati Wesa PikatanDivision of Urology, Department of Surgery, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta 55281, Indonesia.ORCID 0000-0002-2149-325X
Vijesh Kumar YadavDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, New Taipei City 235, Taiwan.ORCID 0000-0002-2679-1205
Tung-Cheng ChangDivision of Colorectal Surgery, Department of Surgery, Taipei Medical University Shuang-Ho Hospital, New Taipei City 235, Taiwan.ORCID 0000-0003-2185-0832

Funding

National Taiwan University of Science and Technology 111TMU-SHH-23
6 · The paper itself

Abstract

Colorectal cancer (CRC) progression and therapy resistance are driven in part by metabolic reprogramming and the persistence of cancer stem-like cells (CSCs). The seven in absentia homolog 2 (SIAH2)/with-no-lysine kinase 1 (WNK1) signaling axis has emerged as a potential regulator of these processes, yet its functional role in CRC metabolism and tumor-stroma crosstalk remains incompletely understood. Integrated analyses of The Cancer Genome Atlas-Colon Adenocarcinoma (TCGA-COAD) and Gene Expression Omnibus (GEO, GSE17538) datasets revealed significant upregulation of

Indexed as

Colorectal NeoplasmsDrug Resistance, NeoplasmGlycolysisNuclear ProteinsSignal TransductionUbiquitin-Protein LigasesWNK Lysine-Deficient Protein Kinase 1Cell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMetabolic ReprogrammingNeoplastic Stem CellsSeven in Absentia ProteinsNuclear ProteinsSeven in Absentia ProteinsUbiquitin-Protein LigasesWNK1 protein, humanWNK Lysine-Deficient Protein Kinase 1metastatic colorectal cancer stem cellsSIAH2/WNK1 signalingtumor fibroblasts

Identifiers

PMID41596707
PMCPMC12842563

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.