Evidence map›Paper›PMID 41596682›Full record

ArticleInternational journal of molecular sciences2026

The Genetic and Molecular Analyses of Rare Candidate Germline

Wejdan M Alenezi, Larissa Milano, Caitlin T Fierheller, Corinne Serruya, Timothée Revil, Kathleen K Oros, Jeffrey P Bruce, Dan Spiegelman, Trevor Pugh, Anne-Marie Mes-Masson and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Case Report: Clinical impact ofFrontiers in oncology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Wejdan M AleneziDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.
Larissa MilanoDepartment of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec City, QC G1V 0A6, Canada.
Caitlin T FierhellerDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.
Corinne SerruyaCancer Research Program, Centre for Translational Biology, The Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada.
Timothée RevilDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0003-1210-7748
Kathleen K OrosLady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC H3T 1E2, Canada.ORCID 0009-0001-6765-8654
Jeffrey P BrucePrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.
Dan SpiegelmanDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.
Trevor PughPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada.ORCID 0000-0002-8073-5888
Anne-Marie Mes-MassonCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Institut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.ORCID 0000-0002-6498-266X
Diane ProvencherCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Institut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.
William D FoulkesDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.
Zaki El HaffafCentre de Recherche du Centre Hospitalier de l'Université de Montréal, Institut du Cancer de Montréal, Montreal, QC H2X 0A9, Canada.
Guy RouleauDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0001-8403-1418
Luigi BouchardDepartment of Biochemistry and Functional Genomics, Université de Sherbrooke, Sherbrooke, QC J1E 4K8, Canada.
Celia M T GreenwoodLady Davis Institute for Medical Research of the Jewish General Hospital, Montreal, QC H3T 1E2, Canada.ORCID 0000-0002-2427-5696
Jiannis RagoussisDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.ORCID 0000-0002-8515-0934
Jean-Yves MassonDepartment of Molecular Biology, Medical Biochemistry and Pathology, Laval University Cancer Research Center, Quebec City, QC G1V 0A6, Canada.
Patricia N ToninDepartment of Human Genetics, McGill University, Montreal, QC H3A 0C7, Canada.

Funding

The Canadian Institute for Health Research; the Fond de la recherche du Québec en santé; Department of Medicine, McGill University; Quebec Breast Cancer Foundation network; Compute Canada resource allocation project wst-164; Genome Canada Genome Technolog PJT-156124; PJT-517664; MOP-115071; PJT-152989; PJT-190076; 20697; 1-15-ACE-26;
6 · The paper itself

Abstract

Five rare variants in

Indexed as

Breast NeoplasmsFanconi Anemia Complementation Group ProteinsGerm-Line MutationOvarian NeoplasmsRNA HelicasesFemaleGenetic Predisposition to DiseaseHumansBRIP1 protein, humanFanconi Anemia Complementation Group ProteinsRNA HelicasesBACH1BRIP1cancer predisposing genecisplatin sensitivityFANCJFrench Canadiangenetic driftmitomycin C sensitivityovarian and breast cancer

Identifiers

PMID41596682
PMCPMC12842359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.