Evidence map›Paper›PMID 41596665›Full record

ArticleInternational journal of molecular sciences2026

Redefining the Collagen Composition of Human Fasciae: Emerging Collagen Types and Structural Heterogeneity.

Caterina Fede, Claudia Clair, Lucia Petrelli, Yunfeng Sun, Carlo Biz, Andrea Angelini, Pietro Ruggieri, Carla Stecco

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Caterina FedeDepartment of Neuroscience, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-4372-7889
Claudia ClairDepartment of Neuroscience, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Lucia PetrelliDepartment of Neuroscience, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.
Yunfeng SunDepartment of Neuroscience, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-2218-781X
Carlo BizDepartment of Orthopedics and Orthopedic Oncology, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-8517-0057
Andrea AngeliniDepartment of Orthopedics and Orthopedic Oncology, University of Padova, 35128 Padova, Italy.ORCID 0000-0002-8823-448X
Pietro RuggieriDepartment of Orthopedics and Orthopedic Oncology, University of Padova, 35128 Padova, Italy.ORCID 0000-0001-9617-9882
Carla SteccoDepartment of Neuroscience, Institute of Human Anatomy, University of Padova, 35121 Padova, Italy.ORCID 0000-0002-8767-4555

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fascia has traditionally been described as a passive connective tissue mainly composed of collagen types I and III. Recent research, however, has revealed its structural and functional complexity, suggesting the possible presence of additional collagen types. This study aimed to quantify the presence and distribution of collagen types I, III, VI, and XII in human superficial and deep fasciae to improve understanding of fascial extracellular matrix composition. Superficial and deep fascia samples were collected from 19 adult patients (ages 20-83 years; thigh and lumbar area). Histology, Azan Mallory staining, hydroxyproline quantification, Western blotting, and immunohistochemistry were performed. The results indicated that deep fascia contained significantly more total collagen than superficial fascia (0.55 ± 0.17 µg/mg vs. 0.36 ± 0.14 µg/mg,

Indexed as

CollagenFasciaAdultAgedAged, 80 and overCollagen Type ICollagen Type IIICollagen Type VIExtracellular MatrixFemaleHumansImmunohistochemistryMaleMiddle AgedYoung AdultCollagenCollagen Type ICollagen Type IIICollagen Type VIcollagencollagen type VIcollagen type XIIdeep fasciaextracellular matrixfasciasuperficial fascia

Identifiers

PMID41596665
PMCPMC12842560

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.