ArticleInternational journal of molecular sciences2026
Osthole Activates FGF21 Expression by Mediating Activation of ATF4 in Human Hepatocyte HepG2 Cells.
Akishi Taguchi, Masaya Araki, Tomoya Yamashita, Ryo Kanazawa, Itsuki Terao, Kyohei Suzuki, Yuhei Tsuchimoto, Takashi Matsuzaka, Hirohito Sone, Hitoshi Shimano and 1 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Akishi TaguchiDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Masaya ArakiDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0009-0004-4376-4278 Tomoya YamashitaDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Ryo KanazawaDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Itsuki TeraoDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Kyohei SuzukiDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Yuhei TsuchimotoDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
Takashi MatsuzakaDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.
Hirohito SoneDepartment of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Niigata 951-8510, Japan.ORCID 0000-0003-1263-2817 Hitoshi ShimanoDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Ibaraki 305-8575, Japan.ORCID 0000-0002-5562-5572 Yoshimi NakagawaDivision of Complex Biosystem Research, Department of Research and Development, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0001-8710-5232 Funding
Japan Society for the Promotion of Science 21H04861
6 · The paper itselfAbstract
Osthole is a natural coumarin derivative found in several medicinal plants, including
Indexed as
Activating Transcription Factor 4CoumarinsFibroblast Growth FactorsHepatocytesGene Expression RegulationHep G2 CellsHumansSignal TransductionActivating Transcription Factor 4ATF4 protein, humanCoumarinsfibroblast growth factor 21Fibroblast Growth FactorsostholATF4coumarin derivativeFGF21gene expressionostholesignal transduction
Identifiers
PMID41596648
PMCPMC12842164
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