Evidence map›Paper›PMID 41596645›Full record

ArticleInternational journal of molecular sciences2026

Mutation-Induced Resistance of SARS-CoV-2 M

Mengting Liu, Derui Zhao, Hui Duan, Junyao Zhu, Liting Zheng, Nan Yuan, Yuanling Xia, Peng Sang, Liquan Yang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengting LiuCollege of Pharmacy, Dali University, Dali 671003, China.
Derui ZhaoCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.
Hui DuanCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.
Junyao ZhuCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.
Liting ZhengCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.
Nan YuanCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.
Yuanling XiaState Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, School of Life Sciences, Yunnan University, Kunming 650091, China.ORCID 0000-0003-3196-7065
Peng SangCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.
Liquan YangCollege of Agriculture and Biological Science, Dali University, Dali 671003, China.

Funding

National Natural Science Foundation of China 31860243National Natural Science Foundation of China 31960198State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan 2024KF003
6 · The paper itself

Abstract

The clinical durability of SARS-CoV-2 main protease (M

Indexed as

Coronavirus 3C ProteasesDrug Resistance, ViralMutationSARS-CoV-2Amino Acid SubstitutionBenzamidesHumansIsoquinolinesMolecular Dynamics SimulationProtein BindingBenzamidesCoronavirus 3C ProteasesIsoquinolinesN-((1S,2R)-2-(4-bromo-2-(methylcarbamoyl)-6-nitro-anilino)cyclohexyl)isoquinoline-4-carboxamidedrug resistance mutationsneural relational inference (NRI) modelnoncovalent inhibitorprotein-inhibitor interaction networkWU-04

Identifiers

PMID41596645
PMCPMC12842141

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.