Evidence map›Paper›PMID 41596643›Full record

ArticleInternational journal of molecular sciences2026

Defining the Critical Role of α-Gustducin for NF-κB Inhibition and Anti-Inflammatory Signal Transduction by Bitter Agonists in Lung Epithelium.

Yuzhen Fang, Qiujie Wang, Shuobin Wu, Xinxiu He, Shengyu Wang, Ruonan Ma, Hao Zhao, Xiaoyi Zhao, Xing Wang, Yuxin Zhang

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuzhen FangKey Laboratory of Ethnomedicine in Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.
Qiujie WangKey Laboratory of Ethnomedicine in Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.
Shuobin WuKey Laboratory of Ethnomedicine in Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.
Xinxiu HeKey Laboratory of Ethnomedicine in Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.
Shengyu WangKey Laboratory of Ethnomedicine in Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.
Ruonan MaBeijing Key Lab of Traditional Chinese Medicine Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Hao ZhaoBeijing Key Lab of Traditional Chinese Medicine Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Xiaoyi ZhaoBeijing Key Lab of Traditional Chinese Medicine Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Xing WangBeijing Key Lab of Traditional Chinese Medicine Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
Yuxin ZhangKey Laboratory of Ethnomedicine in Ministry of Education, School of Pharmacy, Minzu University of China, Beijing 100081, China.ORCID 0000-0003-4067-1047

Funding

National Natural Science Foundation of China 82204644National Natural Science Foundation of China 82374112
6 · The paper itself

Abstract

This study evaluates and compares the protective effects of several type II taste receptor (T2R) agonists against LPS (lipopolysaccharide)-induced inflammatory damage in BEAS-2B cells, focusing on their action via an α-gustducin (encoded by

Indexed as

Anti-Inflammatory AgentsLungNF-kappa BReceptors, G-Protein-CoupledRespiratory MucosaSignal TransductionTransducinCell LineEpithelial CellsHumansInterleukin-6LipopolysaccharidesPhosphorylationTaste Receptors, Type 2Anti-Inflammatory AgentsgustducinInterleukin-6LipopolysaccharidesNF-kappa BReceptors, G-Protein-CoupledTaste Receptors, Type 2TransducinBEAS-2Bbitter taste receptorGNAT3inflammationNF-κB

Identifiers

PMID41596643
PMCPMC12842234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.