Evidence map›Paper›PMID 41596638›Full record

ArticleInternational journal of molecular sciences2026

IFNAR2 p.F8S Variant Associates with Severe COVID-19 and Adaptive Immune Cell Activation Modulation.

Francesco Malvestiti, Angela Lombardi, Francesco Gentile, Veronica Torcianti, Elena Trombetta, Alessandro Cherubini, Giuseppe Lamorte, Sara Colonia Uceda Renteria, Daniele Marchelli, Lorenzo Rosso and 12 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Francesco MalvestitiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0002-2430-5883
Angela LombardiPrecision Medicine Lab, Transfusion Medicine and Hematology, Biological Resource Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Francesco GentileDivision of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Veronica TorciantiPrecision Medicine Lab, Transfusion Medicine and Hematology, Biological Resource Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Elena TrombettaFlow Cytometry Laboratory, Clinical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-1933-6415
Alessandro CherubiniPrecision Medicine Lab, Transfusion Medicine and Hematology, Biological Resource Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0003-4756-2046
Giuseppe LamortePrecision Medicine Lab, Transfusion Medicine and Hematology, Biological Resource Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Sara Colonia Uceda RenteriaVirology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0002-2027-8478
Daniele MarchelliDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0009-0004-9876-171X
Lorenzo RossoDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.
Alessandra BanderaInfectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Flora PeyvandiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0001-7423-9864
Francesco BlasiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0002-2285-9970
Giacomo GrasselliDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.
Laura PorrettiFlow Cytometry Laboratory, Clinical Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-8100-4262
Saleh AlqahtaniLiver, Digestive, and Lifestyle Health Research Section, and Organ Transplant Center of Excellence, King Faisal Specialist Hospital & Research Center, Riyadh 11211, Saudi Arabia.ORCID 0000-0003-2017-3526
Daniele PratiPrecision Medicine Lab, Transfusion Medicine and Hematology, Biological Resource Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Roberta GualtierottiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0001-6465-7624
Blagoje SoskicHuman Technopole, Viale Rita Levi-Montalcini 1, 20157 Milan, Italy.
Valentina VairaDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.ORCID 0000-0003-4416-6216
Luisa RonzoniPrecision Medicine Lab, Transfusion Medicine and Hematology, Biological Resource Centre, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.ORCID 0000-0001-7820-6533
Luca ValentiDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, 20122 Milan, Italy.

Funding

Italian Ministry of Health (Ministero della Salute) RF-2016-02364358
6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has a wide range of clinical manifestations modulated by genetic factors. The aim of this study was to identify genetic determinants of severe COVID-19 affecting protein sequence to gain insight into disease pathogenesis. Variants prioritized in two patients requiring lung transplant were tested in the Milan FOGS cohort (487/869 cases/controls), highlighting an independent association between the p.F8S low-frequency variant of interferon alpha receptor 2 gene (

Indexed as

Adaptive ImmunityCOVID-19Receptor, Interferon alpha-betaAdultAgedDendritic CellsFemaleHumansInterleukin-6Lymphocyte ActivationMaleMiddle AgedSARS-CoV-2IFNAR2 protein, humanInterleukin-6Receptor, Interferon alpha-betaCOVID-19dendritic cellsIFNAR2immunitySARS-CoV-2

Identifiers

PMID41596638
PMCPMC12841681

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.