Evidence map›Paper›PMID 41596618›Full record

ReviewInternational journal of molecular sciences2026

The Diagnostic and Prognostic Role of Combined

Ludovica Pepe, Vincenzo Fiorentino, Cristina Pizzimenti, Maurizio Martini, Mariacarmela Santarpia, Antonina Fazio, Mario Vaccaro, Maria Lentini, Antonio Ieni

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ludovica PepeAnatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Vincenzo FiorentinoAnatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0002-1132-1761
Cristina PizzimentiAnatomic Pathology Unit, Papardo Hospital, 98158 Messina, Italy.ORCID 0000-0002-4387-7174
Maurizio MartiniAnatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.ORCID 0000-0002-6260-6310
Mariacarmela SantarpiaMedical Oncology Unit, Department of Human Pathology "G. Barresi", University of Messina, 98122 Messina, Italy.
Antonina FazioDepartment of Human Pathology, Plastic Surgery Unit, University of Messina, Policlinico Hospital, 98122 Messina, Italy.
Mario VaccaroDepartment of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy.ORCID 0000-0003-3787-5145
Maria LentiniAnatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.
Antonio IeniAnatomic Pathology Unit, Department of Human Pathology in Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanocytic Tumors of Uncertain Malignant Potential (MELTUMPs) remain among the most challenging entities in dermatopathology due to overlapping morphologic features and marked inter-observer variability. This comprehensive review critically assesses the diagnostic and potential prognostic significance of combining p16 and methylthioadenosine phosphorylase (MTAP) immunohistochemistry (IHC) as a practical surrogate for genomic alterations involving the 9p21 (

Indexed as

Biomarkers, TumorCyclin-Dependent Kinase Inhibitor p16MelanomaPurine-Nucleoside PhosphorylaseSkin NeoplasmsHumansImmunohistochemistryPrognosis5'-methylthioadenosine phosphorylaseBiomarkers, TumorCDKN2A protein, humanCyclin-Dependent Kinase Inhibitor p16Purine-Nucleoside Phosphorylase9p21 locusCDKN2Adiagnostic uncertaintyMelanocytic Tumors of Uncertain Malignant Potential (MELTUMP)MTAP (Methylthioadenosine phosphorylase)p16 immunohistochemistryprognostic markers

Identifiers

PMID41596618
PMCPMC12841788

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.