Evidence map›Paper›PMID 41596594›Full record

ArticleInternational journal of molecular sciences2026

Anti-Inflammatory Effects of Alpha-Lipoic Acid Modulate Cystathionine-γ-Lyase Expression in RAW 264.7 Macrophages.

Aqsa Shahid, Stephen Chambers, Amy Scott-Thomas, Masuma Zawari, Madhav Bhatia

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aqsa ShahidDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch 8140, New Zealand.
Stephen ChambersDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch 8140, New Zealand.
Amy Scott-ThomasDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch 8140, New Zealand.ORCID 0000-0002-3246-2491
Masuma ZawariDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch 8140, New Zealand.
Madhav BhatiaDepartment of Pathology and Molecular Medicine, University of Otago, Christchurch 8140, New Zealand.

Funding

University of Otago Research Grant
6 · The paper itself

Abstract

Alpha-lipoic acid (ALA) is a naturally occurring organosulfur compound with antioxidant and anti-inflammatory activities. The time-dependent effects of ALA and mechanism of interaction with cystathionine-γ-lyase (CSE-an enzyme responsible for hydrogen sulfide-H

Indexed as

Anti-Inflammatory AgentsCystathionine gamma-LyaseMacrophagesThioctic AcidAnimalsAntioxidantsCatalaseChemokine CCL2InflammationInterleukin-6LipopolysaccharidesMalondialdehydeMiceOxidative StressRAW 264.7 CellsTumor Necrosis Factor-alphaAnti-Inflammatory AgentsAntioxidantsCatalaseChemokine CCL2Cystathionine gamma-LyaseInterleukin-6LipopolysaccharidesMalondialdehydeThioctic AcidTumor Necrosis Factor-alphaAlpha-lipoic acidanti-inflammatory agentantioxidant agentcystathionine-γ-LyaseLPS-stimulated macrophages

Identifiers

PMID41596594
PMCPMC12842497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.