Evidence map›Paper›PMID 41596573›Full record

ReviewInternational journal of molecular sciences2026

Spatiotemporal Regulation and Lineage Specification in Embryonic Endochondral Ossification.

Sixun Wu, Keita Kondo, Yuki Matsushita

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sixun WuDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Keita KondoDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Yuki MatsushitaDepartment of Skeletal Development and Regenerative Biology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.ORCID 0000-0001-9577-3249

Funding

Japan Society for the Promotion of Science 25H01073Japan Society for the Promotion of Science 25K22763
6 · The paper itself

Abstract

Long bone formation in vertebrates proceeds via endochondral ossification, a sequential process that begins with mesenchymal condensation, advances through cartilage anlage formation, and culminates in its replacement by mineralized bone. Recent advances in inducible lineage tracing and single-cell genomics have revealed that, rather than being a uniform event, mesenchymal condensation rapidly segregates into progenitor pools with distinct fates. Centrally located Sox9

Indexed as

Cell LineageOsteogenesisAnimalsGene Expression Regulation, DevelopmentalHumansSignal Transductioncartilage anlagedorsoventral patterningendochondral ossificationlineage tracingmesenchymal condensationskeletal disorders

Identifiers

PMID41596573
PMCPMC12842144

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.