Evidence map›Paper›PMID 41596563›Full record

ArticleInternational journal of molecular sciences2026

Antibiotic-Mediated Modulation of the Gut Microbiome Identifies Taurine as a Modulator of Adipocyte Function Through TGR5 Signaling.

Elisabeth Jäger, Viktoriya Peeva, Thorsten Gnad, Sven-Bastiaan Haange, Ulrike Rolle-Kampczyk, Claudia Stäubert, Petra Krumbholz, John T Heiker, Claudia Gebhardt, Ute Krügel and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elisabeth JägerDivision of Endocrinology, Nephrology, Rheumatology, Medical Department III, University Hospital of Leipzig, 04103 Leipzig, Germany.ORCID 0000-0001-7342-3459
Viktoriya PeevaDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine I, University Medical Center Bonn, 53127 Bonn, Germany.ORCID 0000-0001-8007-017X
Thorsten GnadInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Sven-Bastiaan HaangeDepartment of Molecular Toxicology, Helmholtz Center for Environmental Research-UFZ, 04318 Leipzig, Germany.ORCID 0000-0003-2952-1152
Ulrike Rolle-KampczykDepartment of Molecular Toxicology, Helmholtz Center for Environmental Research-UFZ, 04318 Leipzig, Germany.ORCID 0000-0002-7728-6284
Claudia StäubertRudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany.ORCID 0000-0003-0721-8507
Petra KrumbholzRudolf Schönheimer Institute of Biochemistry, Faculty of Medicine, Leipzig University, 04103 Leipzig, Germany.
John T HeikerHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-2822-3006
Claudia GebhardtHelmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.
Ute KrügelRudolf Boehm Institute of Pharmacology and Toxicology, Faculty of Medicine, Leipzig University, 04107 Leipzig, Germany.ORCID 0000-0002-2317-2302
Paromita SenDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine I, University Medical Center Bonn, 53127 Bonn, Germany.
Monika HarazinDepartment of Medicine, Endocrinology and Diabetes, Bergmannsheil University Hospitals Bochum, Ruhr University Bochum, 44801 Bochum, Germany.
Viktoria StabDepartment of Medicine, Endocrinology and Diabetes, Bergmannsheil University Hospitals Bochum, Ruhr University Bochum, 44801 Bochum, Germany.
Julia MünzkerDivision of Endocrinology, Nephrology, Rheumatology, Medical Department III, University Hospital of Leipzig, 04103 Leipzig, Germany.
Nazha HamdaniDepartment of Cellular and Translational Physiology, Institute of Physiology, Molecular and Experimental Cardiology, Medical Faculty, Ruhr University Bochum, 44801 Bochum, Germany.ORCID 0000-0002-3053-0008
Alexander PfeiferInstitute of Pharmacology and Toxicology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Martin von BergenDepartment of Molecular Toxicology, Helmholtz Center for Environmental Research-UFZ, 04318 Leipzig, Germany.
Andreas TillDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine I, University Medical Center Bonn, 53127 Bonn, Germany.ORCID 0000-0002-0139-9143
Wiebke K FenskeDivision of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine I, University Medical Center Bonn, 53127 Bonn, Germany.

Funding

BMBF 01EO1501DFG AOBJ: 209933838DFG AOBJ: 335447717DFG AOBJ: 432325352DFG AOBJ: 450149205DFG AOBJ: 624808DFG AOBJ: 624810
6 · The paper itself

Abstract

Gut microbiota has emerged as a modulator of host metabolism and energy balance. However, the precise microbial metabolites mediating thermogenic activation in obesity remain largely undefined. We investigated the effect of antibiotic treatment under a high-fat diet on metabolites and its contribution to lipolysis and thermogenesis. Antibiotic treatment in high-fat diet-fed rats reduced adiposity and enhanced adaptive thermogenesis. Metabolomics revealed elevated taurine levels in the cecum content and plasma of antibiotic-treated animals, correlating with increased expressions of UCP1 and TGR5 in brown adipose tissue. Taurine enhanced lipolysis and oxygen consumption in mouse adipose tissue and human adipocytes. Thereby, taurine modulated lipolysis dependent on TGR5 signaling in adipose tissue. Human data confirmed that taurine promotes browning of white adipocytes and that acute cold exposure leads to a marked drop in circulating taurine, suggesting its rapid recruitment into thermogenic tissues. Besides its synthesis in the liver and dietary uptake, taurine can be a microbiota-derived metabolite that activates adipose thermogenesis and lipolysis through TGR5 and possibly taurine transporter-dependent mechanisms. These findings uncover a gut-adipose axis with therapeutic potential for metabolic disease.

Indexed as

AdipocytesAnti-Bacterial AgentsGastrointestinal MicrobiomeReceptors, G-Protein-CoupledTaurineAdipose Tissue, BrownAnimalsDiet, High-FatHumansLipolysisMaleMiceObesityRatsSignal TransductionThermogenesisAnti-Bacterial AgentsGPBAR1 protein, humanGpbar1 protein, mouseGpbar1 protein, ratReceptors, G-Protein-CoupledTaurinelipolysismicrobiomeobesitytaurineTGR5thermogenesis

Identifiers

PMID41596563
PMCPMC12842370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.