Evidence map›Paper›PMID 41596514›Full record

ArticleInternational journal of molecular sciences2026

Bioactive Compounds of

Che-Yi Chao, Woei-Cheang Shyu, Chih-Lung Lin, Wen-Ping Jiang, Atsushi Inose, Song-Jie Chiang, Wen-Liang Wu, Jaung-Geng Lin, Guan-Jhong Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Antioxidants (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Che-Yi ChaoDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung 413, Taiwan.ORCID 0000-0002-1819-7046
Woei-Cheang ShyuTranslational Medicine Research Center, China Medical University Hospital, Taichung 413, Taiwan.
Chih-Lung LinDepartment of Neurosurgery, Asia University Hospital, Taichung 413, Taiwan.ORCID 0000-0003-0649-4243
Wen-Ping JiangDepartment of Pharmacy, China Medical University, Taichung 404, Taiwan.ORCID 0000-0001-9387-680X
Atsushi InoseFaculty of Pharmacy, Nihon Pharmaceutical University, Saitama 362-0806, Japan.
Song-Jie ChiangDepartment of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Wen-Liang WuSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.
Jaung-Geng LinSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan.ORCID 0000-0002-3642-8047
Guan-Jhong HuangDepartment of Food Nutrition and Health Biotechnology, Asia University, Taichung 413, Taiwan.ORCID 0000-0002-9822-3485

Funding

Asia University ASIA-111-CMUH-01
6 · The paper itself

Abstract

The emergence of SARS-CoV-2, the etiological agent of COVID-19, has resulted in widespread global infection and millions of deaths. Viral entry is initiated by the interaction between the viral spike (S) protein and the host cell receptor ACE2, followed by TMPRSS2-mediated proteolytic activation that facilitates membrane fusion. Bitter melon (

Indexed as

Angiotensin-Converting Enzyme 2Momordica charantiaPeptidyl-Dipeptidase APhytochemicalsPlant ExtractsSerine EndopeptidasesAnimalsChlorocebus aethiopsCoumaric AcidsCOVID-19COVID-19 Drug TreatmentDown-RegulationHumansMiceQuercetinRutinACE2 protein, humanAngiotensin-Converting Enzyme 2Coumaric Acidsp-coumaric acidPeptidyl-Dipeptidase APhytochemicalsPlant ExtractsQuercetinRutinSerine EndopeptidasesTMPRSS2 protein, humanACE2Momordica charantia L.p-coumaric acidquercetinrutinSARS-CoV-2TMPRSS2

Identifiers

PMID41596514
PMCPMC12842135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.