Evidence map›Paper›PMID 41596509›Full record

ArticleInternational journal of molecular sciences2026

Multi-Marker Evaluation of Creatinine, Cystatin C and β2-Microglobulin for GFR Estimation in Stage 3-4 CKD Using the 2021 CKD-EPI Equations.

Nurulamin Abu Bakar, Nurul Izzati Hamzan, Siti Nurwani Ahmad Ridzuan, Izatus Shima Taib, Zariyantey Abdul Hamid, Anasufiza Habib, Noor Hafizah Hassan

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nurulamin Abu BakarCentre of Diagnostics, Therapeutics and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
Nurul Izzati HamzanSpecial Protein Unit, Specialized Diagnostic Centre, Institute for Medical Research, National Institutes of Health, Jalan Pahang, Kuala Lumpur 50588, Malaysia.ORCID 0009-0006-3157-8819
Siti Nurwani Ahmad RidzuanSpecial Protein Unit, Specialized Diagnostic Centre, Institute for Medical Research, National Institutes of Health, Jalan Pahang, Kuala Lumpur 50588, Malaysia.ORCID 0009-0002-2800-4188
Izatus Shima TaibCentre of Diagnostics, Therapeutics and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.ORCID 0000-0001-9901-766X
Zariyantey Abdul HamidCentre of Diagnostics, Therapeutics and Investigative Studies (CODTIS), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
Anasufiza HabibSpecialized Diagnostic Centre, Institute for Medical Research, National Institutes of Health, Jalan Pahang, Kuala Lumpur 50588, Malaysia.ORCID 0000-0001-5529-5115
Noor Hafizah HassanSpecial Protein Unit, Specialized Diagnostic Centre, Institute for Medical Research, National Institutes of Health, Jalan Pahang, Kuala Lumpur 50588, Malaysia.ORCID 0009-0002-9805-4412

Funding

Institute for Medical Research RSCH ID-25-03258-ROB
6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a progressive disease in which accurate estimation of glomerular filtration rate (GFR) is essential for staging and guiding therapy. Serum creatinine is widely used but influenced by non-renal factors, while cystatin C and β2-microglobulin (β2M) may provide complementary information related to filtration and tubular or inflammatory factors. This study compared the discriminatory performance of creatinine, cystatin C and β2M for separating CKD stage 3 from stage 4 within the 2021 CKD-EPI eGFR framework in 45 adults with CKD stages 3-4. CKD stage classification was defined using the 2021 CKD-EPI creatinine and creatinine-cystatin C equations (eGFRcr, eGFRcr-cys) with a threshold of 30 mL/min/1.73 m

Indexed as

beta 2-MicroglobulinBiomarkersCreatinineCystatin CGlomerular Filtration RateRenal Insufficiency, ChronicAdultAgedFemaleHumansMaleMiddle AgedROC Curvebeta 2-MicroglobulinBiomarkersCreatinineCystatin C2021 CKD-EPI equationschronic kidney disease (CKD)cystatin Cdiagnostic accuracyglomerular filtration rate (GFR)molecular biomarkersROC curveserum creatininestage 3–4 CKDβ2-microglobulin (β2M)

Identifiers

PMID41596509
PMCPMC12841536

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.