Evidence map›Paper›PMID 41596439›Full record

ArticleInternational journal of molecular sciences2026

Development and Application of a Pseudovirus-Based Assay for Modelling SARS-CoV-2 Spike Protein Mediated Drug Screening.

Shokhrukh A Khasanov, Iana L Esaulkova, Alexandrina S Volobueva, Alexander V Slita, Daria V Kriger, Dmitri Tentler, Olga I Yarovaya, Anastasia S Sokolova, Andrey N Gorshkov, Anna S Dolgova and 4 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shokhrukh A KhasanovSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.ORCID 0009-0004-9216-9723
Iana L EsaulkovaSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.ORCID 0000-0002-3645-8342
Alexandrina S VolobuevaSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.
Alexander V SlitaDivision of Pediatric Infectious Diseases, Rambam Health Care Campus, Haifa 3109601, Israel.
Daria V KrigerInstitute of Cytology, Russian Academy of Sciences, 194064 Saint Petersburg, Russia.ORCID 0000-0002-7147-1884
Dmitri TentlerG-INCPM, the Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0003-3976-1205
Olga I YarovayaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia.ORCID 0000-0002-2333-4893
Anastasia S SokolovaN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia.
Andrey N GorshkovA. A. Smorodintsev Influenza Research Institute, 197376 Saint Petersburg, Russia.
Anna S DolgovaSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.ORCID 0000-0001-8730-4872
Irina N LavrentievaSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.
Vladimir G DedkovSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.ORCID 0000-0002-5500-0169
Nariman F SalakhutdinovN. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, 630090 Novosibirsk, Russia.
Vladimir V ZarubaevSaint Petersburg Pasteur Institute, Federal Service for the Oversight of Consumer Protection and Welfare, 197101 Saint Petersburg, Russia.ORCID 0000-0002-5224-3771

Funding

Ministry of Science and Higher Education of the Russian Federation FWUE-2025-0006Russian Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing (Rospotrebnadzor) 121030200272-6
6 · The paper itself

Abstract

Requirements for novel effective antiviral agents against SARS-CoV-2 emphasizes the importance of robust in vitro screening platforms. We developed a test system based on spike-pseudotyped lentiviruses, carrying either

Indexed as

Antiviral AgentsSARS-CoV-2Spike Glycoprotein, CoronavirusAngiotensin-Converting Enzyme 2Cell Line, TumorCOVID-19COVID-19 Drug TreatmentDrug Evaluation, PreclinicalHumansLentivirusViral PseudotypingACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2ACE2antiviralscoronavirusH1299lentiviruspseudotypingSARS-CoV-2spike protein

Identifiers

PMID41596439
PMCPMC12841467

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.