Evidence map›Paper›PMID 41596435›Full record

ArticleInternational journal of molecular sciences2026

Proteome-Wide Serological Profiling Reveals Broad Elevation of EBV Immunity in Idiopathic Pulmonary Fibrosis.

Yomani D Sarathkumara, Kiara M Knuckey, Viviana P Lutzky, Penny L Groves, Maxine E Tan, Daniel C Chambers, Carla Proietti, Denise L Doolan, Simon H Apte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yomani D SarathkumaraInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-9975-3165
Kiara M KnuckeyInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0009-0001-4176-7852
Viviana P LutzkyQueensland Lung Transplant Service, The Prince Charles Hospital, Chermside, QLD 4032, Australia.
Penny L GrovesQueensland Lung Transplant Service, The Prince Charles Hospital, Chermside, QLD 4032, Australia.ORCID 0000-0002-4452-4338
Maxine E TanQueensland Lung Transplant Service, The Prince Charles Hospital, Chermside, QLD 4032, Australia.
Daniel C ChambersQueensland Lung Transplant Service, The Prince Charles Hospital, Chermside, QLD 4032, Australia.ORCID 0000-0002-9553-5870
Carla ProiettiInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-6290-0261
Denise L DoolanInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0001-7354-8817
Simon H ApteQueensland Lung Transplant Service, The Prince Charles Hospital, Chermside, QLD 4032, Australia.ORCID 0000-0003-3105-0820

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with uncertain etiology. Chronic viral infection, including Epstein-Barr virus (EBV), has been implicated as a potential driver of repetitive epithelial injury and dysregulated repair. We sought to evaluate and define the breadth versus specificity of EBV-directed humoral immunity in IPF. We performed proteome-scale serological profiling using an EBV protein microarray (202 proteins) representing all proteins expressed by the EBV proteome (type I and II) on plasma samples from 32 patients with confirmed IPF (87.5% male; mean age 60.9 years) and 15 healthy disease-free controls (40% male; mean age 57.9 years). Per-sample global EBV IgG means were higher in IPF than controls (Welch

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanIdiopathic Pulmonary FibrosisProteomeAgedAntibodies, ViralFemaleHumansImmunity, HumoralImmunoglobulin GMaleMiddle AgedProtein Array AnalysisAntibodies, ViralImmunoglobulin GProteomeantibodyEpstein–Barr virusidiopathic pulmonary fibrosismicroarray

Identifiers

PMID41596435
PMCPMC12841087

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.