Evidence map›Paper›PMID 41596422›Full record

ArticleInternational journal of molecular sciences2026

Modulation of the Receptor Tyrosine Kinase TIE2/

Eduardo Cazalla, Ángel Juan García-Yagüe, Marta Pajares, José Jiménez-Villegas, Maribel Escoll, Ana I Rojo, Antonio Cuadrado

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eduardo CazallaDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.ORCID 0000-0001-9546-3793
Ángel Juan García-YagüeDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.ORCID 0000-0002-7876-0638
Marta PajaresDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.
José Jiménez-VillegasGroup of Neurodegenerative Diseases, Hospital Universitario 12 de Octubre Research Institute (imas12), 28041 Madrid, Spain.ORCID 0000-0003-3967-1832
Maribel EscollDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.ORCID 0000-0003-0043-6878
Ana I RojoDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.ORCID 0000-0002-0312-5867
Antonio CuadradoDepartment of Biochemistry, School of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain.ORCID 0000-0002-4039-7140

Funding

Comunidad de Madrid P2022_BMD-7230Comunidad de Madrid S2017BMD-3827Instituto de Salud Carlos III CP21/00049Spanish Ministry of Economy and Competitiveness PDC2021-121421-I00Spanish Ministry of Economy and Competitiveness PDC2022-1337665-I00Spanish Ministry of Economy and Competitiveness PID2019-110061RB-I00Spanish Ministry of Economy and Competitiveness PID2022-141786OB-I00
6 · The paper itself

Abstract

The transcription factor NRF2 orchestrates diverse cellular homeostatic networks, but its role in angiogenesis remains poorly understood. Genetic and pharmacological modulation of NRF2 in mouse neuroendothelial cells altered the expression of several genes involved in endothelial biology. Among these, the TIE2/

Indexed as

Endothelial CellsNF-E2-Related Factor 2Receptor Protein-Tyrosine KinasesReceptor, TIE-2Signal TransductionAngiogenesisAnimalsGene Expression RegulationMiceNeovascularization, PhysiologicNfe2l2 protein, mouseNF-E2-Related Factor 2Receptor Protein-Tyrosine KinasesReceptor, TIE-2Tek protein, mouseangiogenesisBACH1neuroendotheliumNRF2TIE2/Tek

Identifiers

PMID41596422
PMCPMC12841328

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.