Evidence map›Paper›PMID 41596394›Full record

ArticleInternational journal of molecular sciences2026

Who Am I? Eyebrow Follicles Minimize Donor-Derived DNA for Germline Testing After Hematopoietic Stem Cell Transplantation.

Matthias Mertens, Mona Sadlo, Jörn-Sven Kühl, Klaus Metzeler, Louisa Zschenderlein, Jeanett Edelmann, Claudia Lehmann, Sarah Thull, Mert Karakaya, Clara Velmans and 7 more

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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Matthias MertensMIT Future Tech, MIT Sloan School of Business, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Mona SadloInstitute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.
Jörn-Sven KühlDepartment of Pediatric Oncology, Hematology and Hemostaseology, University of Leipzig, 04103 Leipzig, Germany.
Klaus MetzelerDepartment of Hematology, Cellular Therapy and Hemostaseology, Leipzig University Hospital, 04103 Leipzig, Germany.ORCID 0000-0003-3920-7490
Louisa ZschenderleinInstitute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.
Jeanett EdelmannLeipzig Medical Center, Institute of Legal Medicine, Leipzig University, 04103 Leipzig, Germany.
Claudia LehmannInstitute for Transfusion Medicine, University Hospital Leipzig, 04103 Leipzig, Germany.
Sarah ThullInstitute of Human Genetics, Faculty of Medicine and University Hospital, University of Cologne, 50937 Cologne, Germany.
Mert KarakayaInstitute of Human Genetics, Faculty of Medicine and University Hospital, University of Cologne, 50937 Cologne, Germany.
Clara VelmansInstitute of Human Genetics, Faculty of Medicine and University Hospital, University of Cologne, 50937 Cologne, Germany.ORCID 0000-0002-3352-1035
Theresa TumewuDepartment of Pediatric Oncology, Hematology and Hemostaseology, University of Leipzig, 04103 Leipzig, Germany.
Matthias BöhmeDepartment of Pediatric Oncology, Hematology and Hemostaseology, University of Leipzig, 04103 Leipzig, Germany.
Christina KlötzerDepartment of Pediatric Oncology, Hematology and Hemostaseology, University of Leipzig, 04103 Leipzig, Germany.
Anne WeigertDepartment of Hematology, Cellular Therapy and Hemostaseology, Leipzig University Hospital, 04103 Leipzig, Germany.
Vladan VucinicDepartment of Hematology, Cellular Therapy and Hemostaseology, Leipzig University Hospital, 04103 Leipzig, Germany.ORCID 0000-0002-8398-285X
Julia HentschelInstitute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.ORCID 0000-0002-5706-1424
Mareike MertensDivision of Genetics and Genomics, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0003-4014-8173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Germline genetic testing plays a critical role in diagnosing inherited predispositions and increasingly guides therapeutic and surveillance choices-but becomes technically challenging after allogeneic hematopoietic stem cell transplantation (HSCT), when donor-derived DNA contaminates host tissues. To address this, we compared donor-derived DNA across three accessible tissues-buccal swab, nail, and eyebrow follicles-in recipients after hematopoietic stem cell transplantation using two orthogonal assays (34-SNP next-generation sequencing and a 27-marker short tandem repeat panel) and modeled clinical covariates that influence chimerism. Eyebrow follicles showed consistently low donor DNA (median 1% by NGS; 3% by STR) whereas buccal swabs and nails carried substantially higher donor fractions (+25 and +22 percentage points versus eyebrow, respectively; both

Indexed as

DNAEyebrowsGenetic TestingGerm CellsHematopoietic Stem Cell TransplantationTissue DonorsAdultFemaleHigh-Throughput Nucleotide SequencingHumansMaleMicrosatellite RepeatsNailsPolymorphism, Single NucleotideDNAchimerismgermline diagnosticspost-transplant diagnosticstissue source

Identifiers

PMID41596394
PMCPMC12841102

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.