BTK-Inhibitor Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Targeting Elimination of Autoreactive BAFFR

Yamin Zhang, Jingjing Wen, Biling Jiang, Hao Jiang, Jian Xu, Juan Tao

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yamin ZhangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.ORCID 0000-0002-4170-5897

Jingjing WenDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Biling JiangDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Hao JiangHubei Engineering Research Center for Biomaterials and Medical Protective Materials, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China.

Jian XuInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Juan TaoDepartment of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Funding

China Postdoctoral Science Foundation 2022M721265The National Natural Science Foundation of China 82003366The National Natural Science Foundation of China 82130089The National Natural Science Foundation of China 82203924

6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a chronic and refractory autoimmune disease characterized by multi-organ damage, for which reliably safe and effective treatment remains an unmet need. Autoantibodies, secreted by autoreactive B cells, deposition is the central pathogenesis of organ damage in SLE. Current studies reported B cell receptor and B cell activating factor (BAFF)-mediated signals regulate the activation and survival of B cells and production of autoantibodies. We showed that marginal zone B cells and CD11c

Indexed as

AdenineAgammaglobulinaemia Tyrosine KinaseB-Cell Activating FactorB-LymphocytesLupus Erythematosus, SystemicNanoparticlesProtein Kinase InhibitorsAnimalsAntibodies, AntinuclearAutoantibodiesB-Cell Activation Factor ReceptorDisease Models, AnimalFemaleLiposomesMiceMice, Inbred MRL lprAdenineAgammaglobulinaemia Tyrosine KinaseAntibodies, AntinuclearAutoantibodiesB-Cell Activating FactorB-Cell Activation Factor ReceptorBtk protein, mouseibrutinibLiposomesPiperidinesProtein Kinase InhibitorsTnfrsf13c protein, mouseanti-BAFFR antibodyautoreactive B cellEvobrutinibnanoparticlesystemic lupus erythematosus

Identifiers

PMID41596380

DOI10.3390/ijms27020729

PMCPMC12841580

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.